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Kim, Sang Hoon,Kim, Myung Gu,Kim, Sung Soo,Cha, Sung Ho,Yeo, Seung Geun AVES Publishing Co. 2015 The journal of international advanced otology Vol.11 No.2
<P>To investigate changes in Pseudomonas aeruginosa (PA) and methicillin-resistant Staphylococcus aureus (MRSA) and their antibiotic sensitivities over 13 years in patients diagnosed with chronic suppurative otitis media (CSOM).</P>
Lee, Ho Yun,Kim, Namkug,Goo, Jin Mo,Chie, Eui Kyu,Song, Hye Jong AVES Publishing Co. 2016 Diagnostic and interventional radiology Vol.22 No.3
<P>PURPOSE We aimed to compare various tumor-related radiologic morphometric changes and computed tomography (CT) perfusion parameters before and after treatment, and to determine the optimal imaging assessment technique for the prediction of early response in a rat tumor model treated with radiotherapy. METHODS Among paired tumors of FN13762 murine breast cancer cells implanted bilaterally in the necks of eight Fischer rats, tumors on the right side were treated with a single 20 Gy dose of radiotherapy. Perfusion CT studies were performed on day 0 before radiotherapy, and on days 1 and 5 after radiotherapy. Variables based on the size, including the longest diameter, tumor area, and volume, were measured. Quantitative perfusion analysis was performed for the whole tumor volume and permeabilities and blood volumes (BVs) were obtained. The area under the curve (AUC) difference in the histograms of perfusion parameters and texture analyses of uniformity and entropy were quantified. Apoptotic cell density was measured on pathology specimens immediately after perfusion imaging on day 5. RESULTS On day 1 after radiotherapy, differences in size between the irradiated and nonirradiated tumors were not significant. In terms of percent changes in the uniformity of permeabilities between tumors before irradiation and on day 1 after radiotherapy, the changes were significantly higher in the irradiated tumors than in the nonirradiated tumors (0.085 [-0.417, 0.331] vs. -0.131 [-0.536, 0.261], respectively; P = 0.042). The differences in AUCs of the histogram of voxel-by-voxel vascular permeability and BV in tumors between day 0 and day 1 were significantly higher in treated tumors compared with the control group (permeability, 21.4 [-2.2, 37.5] vs. 9.5 [-8.9, 33.8], respectively, P = 0.030; BV, 52.9 [-6186.0, 419.2] vs. 11.9 [-198.3, 346.7], respectively, P = 0.049). Apoptotic cell density showed a significantly positive correlation with the AUC difference of BV, the percent change of uniformity in permeability and BV (r=0.202, r=0.644, and r=0.706, respectively). CONCLUSION By enabling earlier tumor response prediction than morphometric evaluation, the histogram analysis of CT perfusion parameters appears to have a potential in providing prognostic predictive information in an irradiated rat model.</P>
Kil, Kicheol,Choi, Mi Young,Ho Park, Kyoung AVES Publishing Co. 2016 The journal of international advanced otology Vol.12 No.1
<P>OBJECTIVE: We attempted to induce mesenchymal stem cells (MSCs) from human Wharton's jelly (WJ) to differentiate into neuronal progenitor cells, neurons, and auditory hair cells. MATERIALS and METHODS: MSCs were isolated from WJ from human umbilical cords and cultured in medium containing epidermal growth factor and basic fibroblast growth factor. Differentiation into hair cells and neurons was induced using a neurobasal medium containing glial cell-derived neurotrophic factor, brain-derived neurotrophic factor, and neurotrophic factor 3. Fluorescence-activated cell sorting (FACS), immunocytochemistry, and reverse transcription polymerase chain reaction were performed to characterize the differentiated auditory hair cells and neurons. RESULTS: MSCs isolated from human WJ were confirmed by FACS. Double immunocytochemistry confirmed the expression of the hair cell markers myosin VIIA and TRPA1 and the functional marker C-terminal binding protein 2. Differentiation into neurons was revealed using neurofilament and aIII-tubulin markers. Gene expression of neuronal lineage-specific markers confirmed the neuronal differentiation state. CONCLUSION: MSCs from human WJ can be successfully induced to differentiate into auditory hair cells and neurons in vitro.</P>
Song, Chan Il,Kang, Woo Seok,Lee, Jeong Hyun,Chung, Jong Woo AVES Publishing Co. 2016 The journal of international advanced otology Vol.12 No.2
<P>OBJECTIVE: This study aimed to measure the radiological dimensions of the cochlear aqueduct in Meniere's disease and in low-frequency hearing loss (LFHL) patients and control patients. MATERIALS and METHODS: Groups of 26 patients (32 ears, including 6 with bilateral involvement) with Meniere's disease, 14 patients (18 ears) with LFHL, and 23 patients with unilateral chronic otitis media, as controls, were enrolled. For the measurements, high-resolution computed tomography (HRCT) of the temporal bone was performed. The cochlear aqueduct was evaluated for the following six parameters: medial opening (MO), petrous apex (PA), otic capsule (OC), lateral opening (LO), distance of the cochlear aqueduct (DC), and length of the cochlear aqueduct (LC). RESULTS: The PA, OC, DC, and LC were not significantly different between the groups. LO could not be measured because the LO was not visible in all cases. The MO diameter was narrower in the Meniere's disease group than in the LFHL group (p=0.001) and in the controls (p=0.035). When the dimensions of both ears were measured in patients with unilateral Meniere's disease, no statistically significant difference was found. CONCLUSION: Compared to LFHL and controls, the MO of the cochlear aqueduct was significantly smaller in the Meniere's disease group.</P>
Bonebridge Implantation for Conductive Hearing Loss in a Patient with Oval Window Atresia
AVES Publishing Co. 2015 The journal of international advanced otology Vol.11 No.2
<P>The occurrence of oval window atresia is a rare anomaly with conductive hearing loss. Traditional atresia surgeries involve challenging surgical techniques with risks of irreversible inner ear damage. Recent reports on Bonebridge (Medel, Innsbruck, Austria), a novel implantable bone conduction hearing aid system, assert that the device is safe and effective for conductive hearing loss. We present a case of Bonebridge implantation in an eight-year-old girl with bilateral oval window atresia.</P>