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Skin Barrier Abnormalities in Atopic Dermatitis: Cross Talk with Allergic Inflammation
( Yutaka Hatano ) 한국피부장벽학회 2012 한국피부장벽학회지 Vol.14 No.2
The skin barrier function is totally disturbed in atopic dermatitis (AD). Regarding permeability barrier dysfunction, a significant incidence of genetic abnormality in filaggrin in patients with AD is one of the pivotal discoveries, which is stimulating studies on aspects of barrier dysfunction in AD. Currently, permeability barrier homeostasis is one of the most important issues, not only in cutaneous biology, but also in allergology and immunology. Permeability barrier abrogation not only induces cutaneous inflammation, but is also involved in the induction of Th2 type immunological reactions. Conversely, Th2 or other cytokines abrogate permeability barrier homeostasis. In addition to these "Outside to Inside" and "Inside to Outside" relationships between permeability barrier abrogation and allergic inflammation, a new concept called "Intrinsic" cross talk, is proposed in this review. In the "Intrinsic" cross talk" alteration of one macromolecule in keratinocytes affects permeability barrier homeostasis and, simultaneously, induces or augments inflammation.
Sachi Higuchi,Seiichi Yoshida,Takeo Minematsu,Yutaka Hatano,Akifumi Notsu,Takamichi Ichinose 대한피부과학회 2023 Annals of Dermatology Vol.35 No.4
Background: In Japan, neonates have typically been bathed in a bathtub immediately after birth because bathing is a custom for cleansing impurities. However, dry technique has been introduced into many institutions since 2000. There is little scientific evidence on the ben- efit or harmfulness of either method to neonatal skin, and consequently, opinion remains split on which method is superior. Objective: The purpose of the present study was to determine whether bathing or the dry technique of cleaning is better in maintaining skin health in the early neonatal period. Methods: Transepidermal water loss (TEWL) and skin pH, considered an index of skin bar- rier function, were measured in each group. Tumor necrosis factor (TNF)-alpha and inter- leukin (IL)-6, which are inf lammatory cytokines released by keratinocytes, were measured by skin blotting. Results: TEWL and skin pH of neonates were lower with the dry technique than with bath- ing. The expression level of IL-6 and TNF-α in chest skin of neonates was higher with bath- ing than with the dry technique. Conclusion: These results suggest that the dry technique may maintain skin health better than bathing in the early neonatal period.
( Haruna Matsuda-hirose ),( Tomoko Yamate ),( Mizuki Goto ),( Akira Katoh ),( Hiroyuki Kouji ),( Yuya Yamamoto ),( Takashi Sakai ),( Naoto Uemura ),( Takashi Kobayashi ),( Yutaka Hatano ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.6
Background: The canonical Wnt/β-catenin signaling pathway is a fundamental regulatory system involved in various biological events. ICG-001 selectively blocks the interaction of β-catenin with its transcriptional co-activator cyclic AMP response element-binding protein (CBP). Recent studies have provided convincing evidence of the inhibitory effects of ICG-001 on Wnt-driven disease models, such as organ fibrosis, cancer, acute lymphoblastic leukemia, and asthma. However, the effects of ICG-001 in atopic dermatitis (AD) have not been investigated. Objective: To investigate whether β-catenin/CBP-dependent signaling was contributed in the pathogenesis of AD and ICG-001 could be a therapeutic agent for AD. Methods: We examined the effects of ICG-001 in an AD-like murine model generated by repeated topical application of the hapten, oxazolone (Ox). ICG-001 or vehicle alone was injected intraperitoneally every day during the development of AD-like dermatitis arising from once-daily Ox treatment. Results: Ox-induced AD-like dermatitis characterized by increases in transepidermal water loss, epidermal thickness, dermal thickness accompanied by increased myofibroblast and mast cell counts, and serum levels of thymic stromal lymphopoietin and thymus and activation- regulated chemokine, and decreases in stratum corneum hydration, were virtually normalized by the treatment with ICG-001. Elevated serum levels of periostin tended to be downregulated, without statistical significance. Conclusion: These results suggest that β-catenin/CBP-dependent signaling might be involved in the pathogenesis of AD and could be a therapeutic target. (Ann Dermatol 31(6) 631∼639, 2019)