http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Yi-Yun Tsou (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Chang, Shu-Jen,Huang, Su-Hua,Lin, Ying-Ju,Tsou, Yi-Yun,Lin, Cheng-Wen 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.9
Rheum palmatum, Chinese traditional herb, exhibits a great variety of anti-cancer and anti-viruses properties. This study rates antiviral activity of R. palmatum extracts and its components against Japanese encephalitis virus (JEV) in vitro. Methanol extract of R. palmatum contained higher levels of aloe emodin, chrysophanol, rhein, emodin and physcion than water extract. Methanol extract ($IC_{50}=15.04{\mu}g/ml$) exhibited more potent inhibitory effects on JEV plaque reduction than water extract ($IC_{50}=51.41{\mu}g/ml$). Meanwhile, $IC_{50}$ values determined by plaque reduction assay were $15.82{\mu}g/ml$ for chrysophanol and $17.39{\mu}g/ml$ for aloe-emodin, respectively. Virucidal activity of agents correlated with anti-JEV activity, while virucidal $IC_{50}$ values were $7.58{\mu}g/ml$ for methanol extract, $17.36{\mu}g/ml$ for water extract, $0.75{\mu}g/ml$ for chrysophanol and $0.46{\mu}g/ml$ for aloe-emodin, respectively. In addition, $10{\mu}g/ml$ of extract, chrysophanol or aloe emodin caused 90 % inhibition of JEV yields in cells and significantly activated gamma activated sequence-driven promoters. Hence, methanol extract of R. palmatum and chrysophanol with high therapeutic index might be useful for development of antiviral agents against JEV.
-
Shu-Jen Chang,Su-Hua Huang,Ying-Ju Lin,Yi-Yun Tsou,Cheng-Wen Lin 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.9
Rheum palmatum, Chinese traditional herb,exhibits a great variety of anti-cancer and anti-virusesproperties. This study rates antiviral activity of R. palmatumextracts and its components against Japanese encephalitisvirus (JEV) in vitro. Methanol extract of R. palmatumcontained higher levels of aloe emodin, chrysophanol, rhein,emodin and physcion than water extract. Methanol extract(IC50 = 15.04 lg/ml) exhibited more potent inhibitoryeffects on JEV plaque reduction than water extract(IC50 = 51.41 lg/ml). Meanwhile, IC50 values determinedby plaque reduction assay were 15.82 lg/ml for chrysophanoland 17.39 lg/ml for aloe-emodin, respectively. Virucidalactivity of agents correlated with anti-JEV activity,while virucidal IC50 values were 7.58 lg/ml for methanolextract, 17.36 lg/ml for water extract, 0.75 lg/ml forchrysophanol and 0.46 lg/ml for aloe-emodin, respectively. In addition, 10 lg/ml of extract, chrysophanol or aloeemodin caused 90 % inhibition of JEV yields in cells andsignificantly activated gamma activated sequence-drivenpromoters. Hence, methanol extract of R. palmatum andchrysophanol with high therapeutic index might be usefulfor development of antiviral agents against JEV.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
