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Effect of Temperature and Solvents on Enzymatic Synthesis of Naringin Acetate
Seungmee LEE,Yesol BAEK,Jemin SON,Kyeonga KIM,Hyeseon LEE,Hah Young YOO,Jong-Min OH,Chulhwan PARK 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Flavonoids are antioxidants found in nature, and naringin, a type of flavonoid, has strong antioxidant, antibacterial, and anticancer effects. However, the application of naringin to living organisms has difficulty due to its low solubility and stability in hydrophobic environments. These problems can be overcome by the acylation of naringin. This study aimed to synthesize naringin acetate by acylation of naringin and acyl donor using lipase and to obtain a high conversion through optimization of a synthesis reaction. To optimize the synthesis reaction, parameters that affect synthesis (enzyme type, enzyme concentration, acyl donors, ㏖ar ratio (naringin:acyl donor), reaction temperature, and the solvent) were analyzed with one factor at a time (OFAT) method. Under optimal synthesis conditions, the conversion was obtained over 95%. This study suggested efficient synthesis methods that can obtain higher conversion in a shorter reaction time.