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Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments
Chen Chen,Haifeng Zhang,Hongliang Xu,Yake Zheng,Tianwen Wu 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.4
Background: Ginsenoside Rb1 (Rb1), a dominant component from the extract of Panax ginseng root,exhibits neuroprotective functions in many neurological diseases. This study was intended to investigatewhether Rb1 can attenuate cisplatin-induced memory impairments and explore the potentialmechanisms. Methods: Cisplatin was injected intraperitoneally with a dose of 5 mg/kg/wk, and Rb1 was administeredin drinking water at the dose of 2 mg/kg/d to rats for 5 consecutive wk. The novel objects recognition taskand Morris water maze were used to detect the memory of rats. Nissl staining was used to examine theneuron numbers in the hippocampus. The activities of superoxide dismutase, glutathione peroxidase,cholineacetyltransferase, acetylcholinesterase, and the levels of malondialdehyde, reactive oxygen species,acetylcholine, tumor necrosis factor-a, interleukin-1b, and interleukin-10 were measured by ELISAto assay the oxidative stress, cholinergic function, and neuroinflammation in the hippocampus. Results: Rb1 administration effectively ameliorates the memory impairments caused by cisplatin in bothnovel objects recognition task and Morris water maze task. Rb1 also attenuates the neuronal loss inducedby cisplatin in the different regions (CA1, CA3, and dentate gyrus) of the hippocampus. Meanwhile, Rb1 isable to rescue the cholinergic neuron function, inhibit the oxidative stress and neuroinflammation incisplatin-induced rat brain. Conclusion: Rb1 rescues the cisplatin-induced memory impairment via restoring the neuronal loss byreducing oxidative stress and neuroinflammation and recovering the cholinergic neuron functions.