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        Conversion of osteoporotic-like vertebral fracture severity score to osteoporosis T-score equivalent status: A framework study for older Chinese men

        Xiáng J. Wáng,Jason C.S. Leung,Patti M.S. Lam,Timothy C.Y. Kwok 대한골다공증학회 2023 Osteoporosis and Sarcopenia Vol.9 No.1

        Objectives: To define what portion of older community men with what severity of radiographic osteoporotic-like vertebral fracture (OLVF) correspond to what low T-score status. Methods: There were 755 community Chinese men (age: 76.4 ± 6.7 years) with thoracic and lumbar spine radiographs, and hip and lumbar spine bone mineral density measures. For each vertebra in a subject, a score of 0, -0.5, -1, -1.5, -2, -2.5, and -3 was assigned for no OLVF or OLVF of <20%, ≥ 20 -25%, ≥2 5%-1/3, ≥ 1/3-40%, ≥ 40%-2/3, and ≥ 2/3 vertebral height loss, respectively. OLVFss was defined as the summed score of vertebrae T4 to L5. OLVFss and T-scores were ranked from the smallest to the largest values. Results: OLVFss of -2, -2.5, -3, corresponded to a mean femoral neck T-score of -2.297 (range: -2.355~- 2.247), -2.494 (range: -2.637~ -2.363), and -2.773 (range: -2.898~-2.643), a mean hip T-score of -2.311 (range: -2.420~-2.234), -2.572 (range: -2.708~-2.432), -2.911 (range: -3.134~-2.708), a mean lumbar spine T-score of -2.495 (range: -2.656~-2.403), -2.931 (range: -3.255~-2.664), and -3.369 (range: -3.525~-3.258). The Pearson correlation value of OLVFss and T-score of femoral neck, hip and lumbar spine was r = 0.21, 0.26, and 0.22 (all P < 0.0001). Conclusions: A single severe grade radiological OLVF (≥ 40% height loss) or OLVFss ≤ -2.5 suggest the subject is osteoporotic, and a single collapse grade (≥ 2/3 height loss) OLVF or OLVFss ≤ -3 meets osteoporosis diagnosis criterion. The results highlight the difficulty of diagnosing osteoporotic vertebral fractures among Chinese older men.

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