http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Xiaoming Deng,Zhengyu Jiang,Changli Wang,Na Li,Lulong Bo,Yanping Zha,Jinjun Bian,Yan Zhang,Mengda Xu 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Acetate has been indicated to be elevated and to regulate inflammation in inflammatory and metabolic diseases. The inflammasome serves as a key component of immune homeostasis, and its dysregulation can lead to various inflammatory disorders. However, little is known about the effects of acetate on inflammasome activation and the underlying mechanism. Here, we demonstrate that acetate attenuates inflammasome activation via GPR43 in a Ca2+-dependent manner. Through binding to GPR43, acetate activates the Gq/11 subunit and subsequent phospholipase C-IP3 signaling to decrease Ca2+ mobilization. In addition, acetate activates soluble adenylyl cyclase (sAC), promotes NLRP3 inflammasome ubiquitination by PKA, and ultimately induces NLRP3 degradation through autophagy. In vivo, acetate protects mice from NLRP3 inflammasome-dependent peritonitis and LPS-induced endotoxemia. Collectively, our research demonstrates that acetate regulates the NLRP3 inflammasome via GPR43 and Ca2+-dependent mechanisms, which reveals the mechanism of metabolite-mediated NLRP3 inflammasome attenuation and highlights acetate as a possible therapeutic strategy for NLRP3 inflammasome-related diseases.
Yugao Ma,Jiusong Liu,Hongxing Yu,Changqing Tian,Shanfang Huang,Jian Deng,Xiaoming Chai,Yu Liu,Xiaoqiang He 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.6
The solid-state core of a heat pipe cooled reactor operates at high temperatures over 1000 K withthermal and irradiation-induced expansion during burnup. The expansion changes the gap thicknessbetween the solid components and the material properties, and may even cause the gap closure, whichthen significantly influences the thermal and mechanical characteristics of the reactor core. This studydeveloped an irradiation behavior model for HPRTRAN, a heat pipe reactor system analysis code, tointroduce the irradiation effects such as swelling and creep. The megawatt heat pipe reactor MegaPowerwas chosen as an application case. The coupled irradiation-thermal-mechanical model was developed tosimulate the irradiation effects on the heat transfer and stresses of the whole reactor core. The resultsshow that the irradiation deformation effect is significant, with the irradiation-induced strains up to2.82% for fuel and 0.30% for monolith at the end of the reactor lifetime. The peak temperatures during thelifetime are 1027:3 K for the fuel and 956:2 K for monolith. The gap closure enhances the heat transferbut caused high stresses exceeding the yield strength in the monolith
Preliminary numerical study of single bubble dynamics in swirl flow using volume of fluid method
Li, Zhongchun,Qiu, Zhifang,Du, Sijia,Ding, Shuhua,Bao, Hui,Song, Xiaoming,Deng, Jian Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.4
Spacer grid with mixing vane had been widely used in nuclear reactor core. One of the main feather of spacer grid with mixing vane was that strong swirl flow was formed after the spacer grid. The swirl flow not only changed the bubble generation in the near wall field, but also affected the bubble behaviors in the center region of the subchannel. The interaction between bubble and the swirl flow was one of the basic phenomena for the two phase flow modeling in fuel assembly. To obatin better understanding on the bubble behaviors in swirl flow, full three dimension numerical simulations were conducted in the present paper. The swirl flow was assumed in the cylindral calculation domain. The bubble interface was captured by Volume Of Fluid (VOF) method. The properties of saturated water and steam at different pressure were applied in the simulation. The bubble trajectory, motion, shape and force were obtained based on the bubble parameters captured by VOF. The simulation cases in the present study included single bubble with different size, at different angular velocity conditions and at different pressure conditions. The results indicated that bubble migrated to the center in swirl flow with spiral motion type. The lateral migration was mainly related to shear stress magnitude and bubble size. The bubble moved toward the center with high velocity when the swirl magnitude was high. The largest bubble had the highest lateral migration velocity in the present study range. The effect of pressure was small when bubble size was the same. The prelimenery simulation result would be beneficial for better understanding complex two phase flow phenomena in fuel assembly with spacer grid.