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Regulation Mechanism of Long Noncoding RNAs in Colon Cancer Development and Progression
Jiaming Zhu,Jingjing Liu,Xiaohuan Tang,Xiaofang Qiao,Chao Chen,Yuanda Liu 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.4
Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide, and its high rates of relapse andmetastasis are associated with a poor prognosis. Despite extensive research, the underlying regulatory mechanisms of CRC remainunclear. Long noncoding RNAs (lncRNAs) are a major type of noncoding RNAs that have received increasing attention inthe past few years, and studies have shown that they play a role in many biological processes in CRC. Here, we summarize recentstudies on lncRNAs associated with CRC and the signaling pathways and mechanisms underlying this association. We show thatdysregulated lncRNAs may be new prognostic and diagnostic biomarkers or therapeutic targets for clinical application. This reviewcontributes not only to our understanding of CRC, but also suggests novel signaling pathways associated with lncRNAs thatcan be targeted to block or eradicate CRC.