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- 저자 : Vu Viet Linh Nguyen (검색결과 2 건)
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Thanh, Tran Dang,Linh, Dinh Chi,Yen, Pham Duc Huyen,Bau, Le Viet,Ky, Vu Hong,Wang, Zhihao,Piao, Hong-Guang,An, Nguyen Manh,Yu, Seong-Cho Elsevier 2018 PHYSICA B-CONDENSED MATTER - Vol.532 No.-
<P><B>Abstract</B></P> <P>In this work, we present a detailed study on the magnetic properties and the magnetocaloric effect (MCE) of La<SUB>1−x</SUB>K<SUB>x</SUB>MnO<SUB>3</SUB> compounds with <I>x</I>=0.05–0.2. Our results pointed out that the Curie temperature (<I>T</I> <SUB>C</SUB>) could be controlled easily from 213 to 306K by increasing K-doping concentration (<I>x</I>) from 0.05 to 0.2. In the paramagnetic region, the inverse of the susceptibility can be analyzed by using the Curie-Weiss law, <I>χ</I>(<I>T</I>)=<I>C</I>/(<I>T</I>−<I>θ</I>). The results have proved an existence of ferromagnetic clusters at temperatures above <I>T</I> <SUB>C</SUB>. Based on Banerjee's criteria, we also pointed out that the samples are the second-order phase transition materials. Their magnetic entropy change was calculated by using the Maxwell relation and a phenomenological model. Interestingly, the samples with <I>x</I>=0.1–0.2 exhibit a large MCE in a range of 282–306K, which are suitable for room-temperature magnetic refrigeration applications. The composites obtained from single phase samples (<I>x</I>=0.1–0.2) exhibit the high relative cooling power values in a wide temperature range. From the viewpoint of the refrigerant capacity, the composites formed out of La<SUB>1−x</SUB>K<SUB>x</SUB>MnO<SUB>3</SUB> will become more useful for magnetic refrigeration applications around room-temperature.</P>
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Thuy An Trinh,Thai Minh Duy Le,Hoang Gia Vinh Ho,Thi Cam Thach To,Vu Viet Linh Nguyen,Dai Phu Huynh,Doo Sung Lee 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Faculty of Materials Technology, Ho Chi Minh University of Technology (HCMUT)/Vietnam National University Ho Chi Minh City; <sup>1</sup>School of Chemical Engineering and Theragnostic Macromolecules Research Center, Sungkyunkwan University; <sup>2</sup>Vietnam National University Ho Chi Minh City/National Key Laboratory of Polymer and Composite Materials, Ho Chi Minh University of Technology, Vietnam National University; <sup>3</sup>Faculty of Materials Technology, Ho Chi Minh University of Technology (HCMUT)/ Vietnam National University Ho Chi Minh City/Research Center for Polymeric Materials, Ho Chi Minh University of Technology, Vietnam National University In this research, a novel insulin composite delivery system was prepared and characterized. Insulin drug was loading in chitoshan nanospheres using electrospraying method, a pH- and temperature-sensitive biodegradable hydrogel, which is an oligomer serine-poly(lactide)-poly(ethylene glycol)-poly (lactide)-oligomer serine (OS-PLA-PEG-PLA-OS) pentablock copolymer was used as a matrix to containing chitosan–insulin electro sprayed nanospheres (CIN). The properties of the OS-PLA-PEG-PLA-OS pentablock copolymer and the chitosan–insulin nanoparticles such as sol-gel transition, degradation in vitro and in vivo were characterized. The results showed that the chitosan–insulin nanospheres uniformly distributed in the matrix had a reinforcing effect on the mechanical properties and prolonged the degradation time of the hydrogel depot under body conditions. In addition, the cytotoxicity experiment results indicate that the composite could be used as a biomaterial for drug delivery system. The composite solutions accommodating different concentrations of the chitosan–insulin nanospheres were subcutaneously injected into induced diabetic BALB/c mice to study the in vivo insulin-release profile. The result showed that insulin concentrations in blood plasma were maintained at a steady-state level. Furthermore, the bio-properties of the insulin were retained and it showed a blood glucose level reducing effect for more than 60 hours after injection to a streptozotocin (STZ)-induced diabetic mouse model. The results suggested that this injectable pH–temperature sensitive hydrogel containing chitosan– insulin electro sprayed nanosphere composites has promising potential applications for type 1 diabetes treatment.
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