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Effect of light exposure on metalloporphyrin-treated newborn mice.
Schulz, Stephanie,Wong, Ronald J,Kalish, Flora S,Zhao, Hui,Jang, Kyu Yun,Vreman, Hendrik J,Stevenson, David K Williams Wilkins Co. [etc.] 2012 Pediatric research Vol.72 No.2
<P>Neonatal hyperbilirubinemia arises from increased bilirubin production and decreased bilirubin elimination. Although phototherapy safely and effectively reduces bilirubin levels, recent evidence shows that it has adverse effects. Therefore, alternative treatments are warranted. Metalloporphyrins, competitive inhibitors of heme oxygenase (HO), the rate-limiting enzyme in bilirubin production, effectively reduce bilirubin formation; however, many are photoreactive. Here, we investigated possible photosensitizing effects of chromium mesoporphyrin (CrMP) and zinc deuteroporphyrin bis-glycol (ZnBG).</P>