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        Agreement Level of Inflammatory Bowel Disease Symptom Reports between Children and Their Parents

        Angharad Vernon-Roberts,Emma Rouse,Nerissa L Bowcock,Daniel A Lemberg,Andrew S Day 대한소아소화기영양학회 2023 Pediatric gastroenterology, hepatology & nutrition Vol.26 No.2

        Purpose: Children with inflammatory bowel disease (IBD) frequently undergo clinical assessments, involving triadic communication between clinician, parent, and child. During such encounters parents are traditionally the main communicator of information on their child’s IBD, including subjective symptom reports. The level of agreement between children and their parents for IBD symptoms is poorly understood, and this study aimed to examine this factor. Methods: This was a cross-sectional study among children with IBD, and one parent. A validated paediatric IBD symptom report tool (IBDnow) enabled children and their parent to rate seven pain, well-being, and stool metrics, with dyads completing the tool concurrently. Results were assessed using: Individual agreement: proportion of identical symptom reports by each dyad (ideal score >0.7); Category agreement: percentage of identical reports for IBDnow metrics for the cohort; Inter-rater reliability: Gwet’s AC1 coefficient with higher scores indicating better reliability (maximum=1). Results: Seventy-four parent/child dyads participated; child’s mean age 12.2 years (standard deviation [SD] 2.9, range 6-16), mean time since diagnosis 2.8 years (SD 3), 54% female, 73% had Crohn’s Disease. Mean individual agreement level was 0.6, with 27% of dyads agreeing on ≥6/7 IBDnow metrics. Category agreement was reported by 61% of dyads, 20% of parents overestimated, and 19% underestimated, their child’s symptoms. Inter-rater reliability ranged from fair to good. Conclusion: These results should improve clinician awareness of how IBD symptom reports from parents may introduce bias. Children should be considered the most important source of symptom reports, and tools such as IBDnow utilised to enhance communication.

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        Fecal Calprotectin and Cow’s Milk- Related-Symptoms Score in Children with Cow’s Milk Protein Allergy

        Sahar Zain-Alabedeen,Noha Kamel,Mona Amin,Angharad Vernon-Roberts,Andrew S Day,Abdelmoneim Khashana 대한소아소화기영양학회 2023 Pediatric gastroenterology, hepatology & nutrition Vol.26 No.1

        Purpose: The cow’s milk-related-symptom-score (CoMiSS) tool was developed as an awareness tool for the assessment of cow’s milk-related symptoms in infants or children. Fecal calprotectin (FC) is a noninvasive biomarker of gut inflammation that can be measured in serum and stool. This study aimed to investigate the relationship between FC levels and CoMiSS scores in infants with cow’s milk protein allergy. Methods: Infants (aged 6-12 months) who were allergic to cow’s milk protein were enrolled prospectively. Following completion of the CoMiSS scoring, the infants were divided into group 1 (positive CoMiSS scores ≥12) and group 2 (negative CoMiSS scores <12). FC was measured using immunoassay. Results: Of the 120 infants enrolled in this study, 60 (50.0%) had positive CoMiSS scores (group 1), while 60 (50.0%) had negative scores (group 2). The mean FC level was higher in the infants in group 1 than those in group 2 (2,934.57 μg/g vs. 955.13 μg/g; p<0.001). In addition, there was a positive correlation between FC and CoMiSS scores (R=0.168, p<0.0001). A FC level of 1,700 μg/g provided a sensitivity of 98.3%, specificity of 93.3%, and accuracy of 95.8% for the diagnosis of cow’s milk protein allergy (CMPA). Conclusion: FC measurement may have a role in the assessing infants with CMPA.

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        Distribution of two European elaterids, Agriotes obscurus and A. lineatus in British Columbia: New records, and potential implications of their dispersal

        van Herk Willem G.,Vernon Robert S.,Acheampong Susanna,Otani Jennifer K.,Uloth Keith 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.3

        Two European click beetle species, Agriotes obscurus L. (AO) and A. lineatus L. (AL) have become serious pests of agriculture in the Fraser Valley and Vancouver Island areas of British Columbia (BC), but prior to the start of this survey (2017) it was unknown if they had established elsewhere in the Province. Pitfall traps baited with sex pheromone of AO and AL were placed throughout BC in 2017–2019 and collected a total of 4,988 AO and 20,103 AL beetles in 150 trap pairs. Both species were found to be distributed throughout southern BC, including high numbers in Creston, Kelowna, Pemberton, and Salmon Arm. Traps placed in northern BC, northern Alberta, northern Idaho, or the Willamette valley in western Oregon did not collect AO or AL. Traps were also deployed for A. sputator L., a related European species that has become a serious pest of potato in eastern Canada, but this species was not collected. AO and AL traps placed in the Pemberton valley of BC also collected 474 A. ferrugineipennis (LeConte), and traps placed in the northern Okanagan valley collected 75 A. oregonensis Becker. Both are native Agriotes species not closely related to AO or AL; this is the first time A. oregonensis was collected in Canada. We discuss the potential implications of the spread of AO and AL to other agricultural areas in BC and beyond.

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