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- 저자 : Varukattu, Nipun Babu (검색결과 1 건)
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Saravanakumar, Kandasamy,Chelliah, Ramachandran,Shanmugam, Sabarathinam,Varukattu, Nipun Babu,Oh, Deog-Hwan,Kathiresan, Kandasamy,Wang, Myeong-Hyeon Elsevier 2018 Journal of photochemistry and photobiology Biology Vol.185 No.-
<P><B>Abstract</B></P> <P>This article reports the utilization of seed extract (GSE) from <I>Gardenia jasminoides</I> Ellis. in the synthesis of silver nanoparticles (Gs-AgNPs) with versatile biological activities. The synthesized Gs-AgNPs were spherical in shape, crystal lattice with an average size of 20 nm as confirmed by UV–vis spectrum, X-ray diffractometer (XRD), Transmission electron microscopy with Energy dispersive X-ray spectroscopy (TEM-EDS) and particle size analyses (PSA). Phenolic compounds, proteins, and terpenoids were likely involved in the Gs-AgNPs synthesis, as indicated by Fourier-transform infrared spectroscopy (FTIR) analysis. The minimum bactericidal concentration (MBC) of the Gs-AgNPs was 12.5 μg·ml<SUP>−1</SUP> for <I>S. enterica Typhimurium</I> and 10 μg·ml<SUP>−1</SUP> for <I>S. aureus</I>. The MBC of the Gs-AgNPs induced >70% bacterial cell death within 60 min, as confirmed by growth curve analysis followed by Confocal laser scanning microscope (CLSM). Gs-AgNPs showed the highest scavenging activity for 1, 2-diphenyl-1-picrylhydrazyl DPPH radical (92.3 ± 0.86%), Nitric oxide (NO) radical (72.5 ± 2.15%), and Hydrogen peroxide H<SUB>2</SUB>O<SUB>2</SUB> radical (85.25 ± 1.45%). Anticancer results revealed an IC<SUB>50</SUB> of 15.625 ± 1.3 μg·ml<SUP>−1</SUP> for Gs-AgNPs, whereas it was 580.54 ± 2.5 μg·ml<SUP>−1</SUP> for GSE. The Gs-AgNPs generated high reactive oxygen species (ROS) resulting in induced apoptosis as evident by up-regulation of apoptosis-related protein. In addition, the photocatalytic results revealed about 92% of the reduction in Coomassie Brilliant Blue dye color with Gs-AgNPs. Hence, this work provided economically viable and ecologically sustainable Gs-AgNPs as an alternative biomaterial for future therapeutic applications as antimicrobial, antioxidant, anti-cancer agents and in dye degradation for water remediation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Green synthesis of Gs-AgNPs using seed extract of <I>Gardenia jasminoides</I>. </LI> <LI> Synthesized Gs-AgNPs characterized using UV–vis, FE-TEM, EDX, XRD, and PSA. </LI> <LI> The antibacterial, anticancer and photocatalytic activity of Gs-AgNPs ascertained. </LI> <LI> Gs-AgNPs showed the high potency towards versatile bioactivity. </LI> <LI> Gs-AgNPs proved as an alternative biomaterial for future bioengineering application. </LI> </UL> </P> <P><B>Graphical abstarct</B></P> <P>[DISPLAY OMISSION]</P>
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