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RISS 인기검색어
- 검색키워드
- 저자 : Ujjalkumar Das (검색결과 3 건)
- 무료
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- 유료
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Suneel Pandey,Ujjalkumar Das,Arun Patil 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.4
Periodontal disease comprises a group ofinflammatory conditions of periodontal tissues with commonetiologic agent (bacteria) in the form of dental plaque. The objective of this research was to prepare a water-in-oiltype microemulsion comprising metronidazole and equateits potency towards the effective treatment of periodontitis. A pseudo ternary phase diagram for microemulsioninvestigated using quaternary system containing water/captex 500/ tween 80/acconon CC6. The microemulsionwas preferred from the microemulsion area on the phasediagram. Stable water-in-oil type metronidazole microemulsionwas prepared successfully using the quaternarysystem of water/captex 500/ tween 80/acconon CC6 at 4:1ratio having droplet size in the range of 81 ± 12.91 to196 ± 10.73 nm, conductivity 50.6 ± 0.8 to 330.7 ±1.1 ls/cm. In-vitro drug release, in vitro and ex vivoantimicrobial activities by agar well diffusion were investigated. Metronidazole Microemulsion loaded hydrogelformulations (F9 and F10) were found to be optimized formaximum release and antimicrobial activity in terms ofzone of inhibition. The in vitro release evidenced thatmetronidazole microemulsion loaded hydrogel release ratewas maximum as compared to other plain metronidazolegels. Stability study proved that microemulsion persistedstable for at least 6 months; with no changes in clarity,characteristic properties, and no sign of crystallization ofmetronidazole. In ex vivo evaluation, microemulsion basedhydrogels were effective against the microbial flora of thehuman oral cavity suffering from periodontitis. The systemwas found to be appropriate for application and moreeffective in reducing the clinical symptoms of periodontitis.
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Mohan Anant,Bhatnagar Anuj,Gupta Tarang,Ujjalkumar Das,Kanswal Sunita,Velpandian Thirumurthy,Guleria Randeep,Singh Urvashi B. 한국약제학회 2022 Journal of Pharmaceutical Investigation Vol.52 No.4
Purpose Patients with pulmonary tuberculosis (PTB) who fail therapy or develop a relapse are initiated on a retreatment regimen. These patients are at high risk for adverse outcomes. This study aimed to assess the relationship between plasma levels of anti-tubercular drugs and therapy outcome in patients on retreatment. Methods Pharmacokinetics of retreatment regimen drugs [isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA), ethambutol (EMB), and streptomycin (STM)] were compared between cured and not-cured patients using liquid chromatographytandem mass spectrometry (LC-MS/MS) in 134 patients with PTB on a retreatment regimen. Results Of 134 patients, 108 were cured, 17 developed multi-drug resistant TB (MDR-TB), and 9 remained smear-positive after completion of the retreatment (8 months). Two-hour plasma levels ( C2hr) at Day 0 were lower in ‘not cured’ subjects than ‘cured’ subjects and reflected the drug levels achieved later in the duration of retreatment. Notably, in the 26 ‘not cured’ subjects, C2hr plasma levels after the first dose at Day 0 were significantly low (INH: 0.86 vs. 2.94 mg/L, p ≤ 0.002, RIF: 0.56 vs. 2.55 mg/L, p ≤ 0.003, PZA: 1.85 vs. 26.58 mg/L, p ≤ 0.001 and EMB: 0.72 vs. 1.53 mg/L, p ≤ 0.010). Conclusion Therapeutic failure in patients with PTB on a retreatment regimen is associated with lower plasma drug levels. Therapeutic drug monitoring would prove useful for obtaining a favorable clinical outcome. C2hr levels on Day 0 reflected drug levels achieved later and could be a good predictor of patient outcome.
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Mucoadhesive buccal tablets of domperidone: formulation evaluation and effects of process variables
Suneel Lakshminarayan Pandey,Nilesh Tikaram Hingawe,Ujjalkumar Das,Arun Triyambak Patil 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.2
The aim of the present work was to develop andevaluate buccal adhesive tablets of domperidone and studythe effect of diluents. Tablets were prepared by direct compressionmethod using different polymer and excipientscombinations. Formulations batches were evaluated forphysical parameter, swelling studies, bioadhesion studiesand in vitro drug release. Formulation batch F2 was mostpromising composition of 1:5 ratio of HPMC K4 M/Sodiumalginate. Effect of formulation variables such as diluents i.e. lactose (water soluble) and di-calcium phosphate (DCP)(water insoluble) studied on swelling index, bioadhesiveperformance and in vitro drug release. Bioadhesive force wasdrastically decreased in presence of DCP; it was concludedthat DCP more significantly affected the swelling index thandid lactose. Both Lactose and DCP similarly affect the bioadhesivestrength of buccal adhesive tablets. Dissolutionprofiles have shown non-fickian drug release mechanism,which indicated that the drug was released by diffusion anderosion mechanism. Thereby buccal adhesive tablets offer apromising strategy for drug delivery of domperidone.
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