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CONSTRAINING SUPERNOVA PROGENITORS: AN INTEGRAL FIELD SPECTROSCOPIC SURVEY OF THE EXPLOSION SITES
KUNCARAYAKTI, H.,ALDERING, G.,ANDERSON, J.P.,ARIMOTO, N.,DOI, M.,GALBANY, L.,HAMUY, M.,HASHIBA, Y.,KRUEHLER, T.,MAEDA, K.,MOROKUMA, T.,USUDA, T. The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
We describe a survey of nearby core-collapse supernova (SN) explosion sites using integral field spectroscopy (IFS) techniques, which is an extension of the work described in Kuncarayakti et al. (2013). The project aims to constrain SN progenitor properties based on the study of the immediate environment of the SN. The stellar populations present at the SN explosion sites are studied by means of integral field spectroscopy, which enables the acquisition of both spatial and spectral information of the object simultaneously. The spectrum of the SN parent stellar population gives an estimate of its age and metallicity. With this information, the initial mass and metallicity of the once coeval SN progenitor star are derived. While the survey is mostly done in optical, the additional utilization of near-infrared integral field spectroscopy assisted with adaptive optics (AO) enables us to examine the explosion sites in high spatial detail, down to a few parsecs. This work is being carried out using multiple 2-8 m class telescopes equipped with integral field spectrographs in Chile and Hawaii.
NEAR-INFRARED HIGH-RESOLUTION SPECTROSCOPY OF THE OBSCURED AGN IRAS 01250+2832
Shirahata, M.,Usuda, T.,Oyabu, S.,Nakagawa, T.,Yamamura, I. The Korean Astronomical Society 2012 天文學論叢 Vol.27 No.4
We provide a new physical insight on the hot molecular clouds near the nucleus of the heavily obscured AGN IRAS 01250+2832, based on the results of near-infrared high-resolution spectroscopy of gaseous CO ro-vibrational absorption lines with Subaru/IRCS. The detected CO absorption lines up to highly excited rotational levels reveal that hot dense molecular clouds exist around the AGN under the peculiar physical conditions.
Activation-induced Apoptosis of Peripheral Lymphocytes Treated with 7-hydroxystaurosporin, UCN-01
Fukumoto, H.,Tamura, T.,Kamiya, Y.,Usuda, J.,Suzuki, T.,Kanazawa, F.,Kuh, H J.,Ohe, Y.,Saijo, N.,K. Nishio 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-
7-hydroxystaurosporine (UCN-01) is a new anticancer agent which exerts an inhibitory effect on cell cycle check points and is currently under phase I clinical trials in US and Japan. Preliminary clinical data indicated that UCN-01 remained in plasma at high concentrations for long periods of time. this unavoidable high plasma drug exposure is likely to lead to hematological toxicties in patients. In the present study, cultured human peripheral blood lymphocytes (PBLs) were used to evaluate the possible hematological toxicities of UCN-01 treatment. UCN-01 treatment. UCN-01 induces apoptosis, and the induction of apoptosis-related surface markers were also examined to investigate the involvement of these molecules in UCN-01-induced apoptosis in PBLs. In vitro viability of PBLs was decreased by high dose of UCN-01 (25 microM, 3-day exposure). This effect of UCN-01 was significantly suppressed by the presence of human serum, suggesting that some specific inhibitory factor(s) in human serum may antagonize the lympholytic effect of UCN-01. The percentage of annexin V-positive PI-negative cells increased with exposure to UCN-01 in a time- and dose-dependent manner; by up to 30.3% after exposure to 25 microM UCN-01 for 3 day. At the same time, the expression of both interleukin-2 receptor (IL-2R, CD25) and Fas (CD95), analyzed by flow cytometry, was induced. Con A-stimulated PBLs were more sensitive to UCN-01-induced apoptosis than non-stimulated lymphocytes and UCN-01 increased the sFas-L released into culture medium from con A-stimulated PBLs. Therefore, lymphocyte depletion mediated by activation-induced apoptosis is likely to occur in patients treated with UCN-01 at high doses. (Investigational New Drugs 17(4):335-341, 1999)