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      • Task Allocation for a Robotic Swarm Based on an Adaptive Response Threshold Model

        Eduardo Castello,Tomoyuki Yamamoto,Yutaka Nakamura,Hiroshi Ishiguro 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10

        Biological systems are often composed of many well-organized elements, for instance the flock of birds or social insect communities such as bees or ants. However, developing a swarm robotic system with similar functions, which could be flexible and adapt to environmental changes is undoubtedly complex. In order to achieve such high goal, a good task allocation method, which can regulate and achieve an efficient labor division is crucial. In this paper we propose an optimized version of the simple Response Threshold Model [8] using a discretized version of the Attractor Selection paradigm, in order to dynamically change the threshold parameter (θ). Simulation experiments are carried out in order to study the effects of these optimization measures on the performance of a foraging mission. Simulation experiments verified that the resultant optimized model can improve the adaptation capabilities of previous systems, making a swarm of robots able to adapt more efficiently to dynamical situations.

      • Low Dose Ultraviolet Al (340-400 nm) Phototherapy for Erythrodermic Cutaneous T-cell Lymphoma

        Uede, Koji,Hiroi, Akihisa,Nakamura, Tomoyuki,Kishi, Tomoo,Yamamoto, Yuki,Furukawa, Fukumi Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2

        Three patients suffering from widespread erythrodermic cutaneous T-cell lymphoma were treated with low-dose UVAI phototherapy with a single dose of 20 - 30J/$cm^2$, resulting in cumulative doses of 520 - 1890 J/$cm^2$. Two patients showed complete responses, while other had a partial improvement.

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        In Vitro Effects of Plasma Collected From Rats Administered Naftopidil on Whole Urinary Bladder Preparation Isolated From Rats

        Tsuyoshi Hattori,Kimio Sugaya,Saori Nishijima,Katsumi Kadekawa,Tomoyuki Ueda,Hideyuki Yamamoto 대한배뇨장애요실금학회 2019 International Neurourology Journal Vol.23 No.4

        Purpose: Alpha-1-adrenoceptor blockers (e.g., naftopidil) are prescribed for the treatment of male lower urinary tract symptoms. Although the mechanism of action of naftopidil has been studied in various organs, that in the urinary bladder remains unknown. To clarify the direct effects of naftopidil on this organ, activities were assessed in the isolated rat whole urinary bladder. Methods: A total of 30 female rats were used. In Experiment 1, bladder activity was measured during a cumulative administration of 2.5–75μM naftopidil (n=7). In Experiment 2, rats were divided into 2 groups: control (n=10) and naftopidil (5 mg/ animal/day, oral gavage, once-daily for 2 weeks) (n=13). After the treatment period, plasma was obtained from each rat. The urinary bladders were harvested from the control rats. Isovolumetric rhythmic bladder contractions were induced at above the threshold volume, and intravesical pressure was recorded. Control plasma was added to the organ bath; after subsequent wash-out, plasma collected from rats administered naftopidil was added. In Experiment 3, the plasma levels of monoamines and amino acids were quantified using the individual plasma prepared in the Experiment 2. Results: Cumulative dosing with naftopidil did not change the interval between spontaneous contractions compared to the interval at baseline. After adding control plasma, the interval was shortened compared to the baseline (P=0.008). The plasma collected from rats administered naftopidil suppressed the shortening of the interval compared to the control plasma (P=0.041). Naftopidil resulted in a decrease in the level of noradrenaline (P=0.009) and an increase in that of glycine (P=0.014). Conclusions: Although naftopidil did not directly act on the interval between spontaneous contractions of the urinary bladder, the plasma collected from rats administered naftopidil, with changing levels of monoamines and amino acids, may suppressed shortening the interval.

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        Emotional Stress Facilitates Micturition Reflex: Possible Inhibition by an α1-Adrenoceptor Blocker in the Conscious and Anesthetized State

        Tsuyoshi Hattori,Kimio Sugaya,Saori Nishijima,Katsumi Kadekawa,Tomoyuki Ueda,Hideyuki Yamamoto 대한배뇨장애요실금학회 2019 International Neurourology Journal Vol.23 No.2

        Purpose: To test the hypothesis that naftopidil prolongs intercontraction intervals in rats undergoing chronic stress as observed in previous animal models, voiding behavior and bladder function were measured and analyzed. Methods: Female Sprague-Dawley rats weighing 200–230 g were exposed to repeated variate stress (RVS) for 1 week, chronic variable mild stress for 2 weeks, or simple mild stress for 1 week. Voiding behavior was assessed in metabolic cages. Voiding frequency and urine output were measured, and changes of these values were compared for the different types of stress. Micturition reflex was analyzed using unconscious cystometry. Naftopidil was administered orally at 30 mg/kg/day for 2 weeks. Results: Unexpectedly, no stress-exposed rats exhibited increased micturition frequency compared to the normal nonstressed control. However, intercontraction intervals were shortened with each type of stress in the unconscious condition, especially by RVS (P<0.01). Naftopidil prolonged the shortened intervals. Conclusions: Although voiding behavior appears approximately normal in rats chronically exposed to emotional stress, internal bladder function can be affected. With anesthesia, micturition intervals were moderately shortened by emotional stress and clearly improved by naftopidil. Therefore, naftopidil appears to act at the spinal level at least.

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