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- 저자 : Ting-Wei Mi (검색결과 2 건)
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Loss of MicroRNA-137 Impairs the Homeostasis of Potassium in Neurons via KCC2
Ting-Wei Mi,Xiao-Wen Sun,Zhi-Meng Wang,Ying-Ying Wang,Xuan-Cheng He,Cong Liu,Shuang-Feng Zhang,Hong-Zhen Du,Chang-Mei Liu,Zhao-Qian Teng 한국뇌신경과학회 2020 Experimental Neurobiology Vol.29 No.2
Neuropsychiatric disorders are the leading cause of mental and intellectual disabilities worldwide. Current therapies against neuropsychiatric disorders are very limited, and very little is known about the onset and development of these diseases, and their most effective treatments. MIR137 has been previously identified as a risk gene for the etiology of schizophrenia, bipolar disorder, and autism spectrum disorder. Here we generated a forebrain-specific MIR137 knockout mouse model, and provided evidence that loss of miR-137 resulted in impaired homeostasis of potassium in mouse hippocampal neurons. KCC2, a potassium-chloride co-transporter, was a direct downstream target of miR-137. The KCC2 specific antagonist VU0240551 could balance the current of potassium in miR-137 knockout neurons, and knockdown of KCC2 could ameliorate anxiety-like behavior in MIR137 cKO mice. These data suggest that KCC2 antagonists or knockdown might be beneficial to neuropsychiatric disorders due to the deficiency of miR-137.
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Effect of polyolefin fibers on the permeability of cement-based composites
Hui-Mi Hsu,Wei-Ting Lin,An Cheng 사단법인 한국계산역학회 2012 Computers and Concrete, An International Journal Vol.9 No.6
This study evaluates the permeability of cement-based composites, which are a mix of polyolefin fibers and silica fume. Test results indicate that permeability increases as the water/cementitious ratio increases. Silica fume in cement-based composites produced hydrated calcium silicate and filled the pores. However, permeability decreased as the addition of silica fume increased. Specimens containing polyolefin fibers also provided higher permeability resistance. The polyolefin fiber length did not have a significant effect on permeability. The decrease in the permeability is mainly due to the addition of silica fume and lower water/cementitious ratio. Addition of fibers marginally decreases the permeability. Incorporating polyolefin fiber and silica fume in composites achieved more significant decreases in permeability. The correlated test results reveal the interrelationship between them.
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