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RISS 인기검색어
- 검색키워드
- 저자 : Thorsson, Vesteinn (검색결과 2 건)
- 무료
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The Immune Landscape of Cancer
Thorsson, Vé,steinn,Gibbs, David L.,Brown, Scott D.,Wolf, Denise,Bortone, Dante S.,Ou Yang, Tai-Hsien,Porta-Pardo, Eduard,Gao, Galen F.,Plaisier, Christopher L.,Eddy, James A.,Ziv, Elad,Culhane, Elsevier 2018 Immunity Vol.48 No.4
<P><B>Summary</B></P> <P>We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes—wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant—characterized by differences in macrophage or lymphocyte signatures, Th1:Th2 cell ratio, extent of intratumoral heterogeneity, aneuploidy, extent of neoantigen load, overall cell proliferation, expression of immunomodulatory genes, and prognosis. Specific driver mutations correlated with lower (<I>CTNNB1</I>, <I>NRAS</I>, or <I>IDH1</I>) or higher (<I>BRAF</I>, <I>TP53</I>, or <I>CASP8</I>) leukocyte levels across all cancers. Multiple control modalities of the intracellular and extracellular networks (transcription, microRNAs, copy number, and epigenetic processes) were involved in tumor-immune cell interactions, both across and within immune subtypes. Our immunogenomics pipeline to characterize these heterogeneous tumors and the resulting data are intended to serve as a resource for future targeted studies to further advance the field.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Six identified immune subtypes span cancer tissue types and molecular subtypes </LI> <LI> Immune subtypes differ by somatic aberrations, microenvironment, and survival </LI> <LI> Multiple control modalities of molecular networks affect tumor-immune interactions </LI> <LI> These analyses serve as a resource for exploring immunogenicity across cancer types </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics
Ding, Li,Bailey, Matthew H.,Porta-Pardo, Eduard,Thorsson, Vesteinn,Colaprico, Antonio,Bertrand, Denis,Gibbs, David L.,Weerasinghe, Amila,Huang, Kuan-lin,Tokheim, Collin,Corté,s-Ciriano, Isidro,J Elsevier 2018 Cell Vol.173 No.2
<P><B>Summary</B></P> <P>The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An overview of PanCancer Atlas analyses on oncogenic molecular processes </LI> <LI> Germline genome affects somatic genomic landscape in a pathway-dependent fashion </LI> <LI> Genome mutations impact expression, signaling, and multi-omic profiles </LI> <LI> Mutation burdens and drivers influence immune-cell composition in microenvironment </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
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