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Desai, Sachin N.,Akalu, Zenebe,Teshome, Samuel,Teferi, Mekonnen,Yamuah, Lawrence,Kim, Deok Ryun,Yang, Jae Seung,Hussein, Jemal,Park, Ju Yeong,Jang, Mi Seon,Mesganaw, Chalachew,Taye, Hawult,Beyene, Dem Allen Press, etc 2015 The American journal of tropical medicine and hygi Vol.93 No.3
<P>Killed whole-cell oral cholera vaccine (OCV) has been a key component of a comprehensive package including water and sanitation measures for recent cholera epidemics. The vaccine, given in a two-dose regimen, has been evaluated in a large number of human volunteers in India, Vietnam, and Bangladesh, where it has demonstrated safety, immunogenicity, and clinical efficacy. We conducted a double-blind randomized placebo-controlled trial in Ethiopia, where we evaluated the safety and immunogenicity of the vaccine in 216 healthy adults and children. OCV was found to be safe and elicited a robust immunological response against <I>Vibrio cholerae</I> O1, with 81% adults and 77% children demonstrating seroconversion 14 days after the second dose of vaccine. This is the first study to evaluate safety and immunogenicity of the vaccine in a population outside Asia using a placebo-controlled, double-blind, randomized study design.</P>