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Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling
Praveen Rai,Drista Sharma,Rani Soni,Nazia Khatoon,Bhaskar Sharma,Tarun Kumar Bhatt 한국미생물학회 2017 The journal of microbiology Vol.55 No.4
Malaria has been present since ancient time and remains amajor global health problem in developing countries. Plasmodiumfalciparum belongs to the phylum Apicomplexan,largely contain disease-causing parasites and characterizedby the presence of apicoplast. It is a very essential organelleof P. falciparum responsible for the synthesis of key moleculesrequired for the growth of the parasite. Indispensablenature of apicoplast makes it a potential drug target. Calciumsignaling is important in the establishment of malaria parasiteinside the host. It has been involved in invasion and egressof merozoites during the asexual life cycle of the parasite. Calcium signaling also regulates apicoplast metabolism. Therefore,in this review, we will focus on the role of apicoplast inmalaria biology and its metabolic regulation through Ca++signaling.