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RISS 인기검색어
- 검색키워드
- 저자 : Streeter, Chris C (검색결과 2 건)
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Cerebellar Gray Matter Volume Correlates with Duration of Cocaine Use in Cocaine-Dependent Subjects
Sim, Minyoung E,Lyoo, In Kyoon,Streeter, Chris C,Covell, Julie,Sarid-Segal, Ofra,Ciraulo, Domenic A,Kim, Minue J,Kaufman, Marc J,Yurgelun-Todd, Deborah A,Renshaw, Perry F American College of Neuropsychopharmacology 2007 Neuropsychopharmacology Vol.32 No.10
This study was conducted to explore differences in gray and white matter volume between cocaine-dependent and healthy comparison subjects using optimized voxel-based morphometry (VBM). Brain magnetic resonance imaging (MRI) and neuropsychological function tests were performed for 40 cocaine-dependent subjects (41.4±6.9 years, 27 men) and 41 healthy age- and sex-matched comparison subjects (38.7±8.8 years, 26 men). Optimally normalized whole brain MR images were segmented, modulated, smoothed, and compared between groups with statistical parametric mapping. The cocaine-dependent group had lower gray matter volumes in bilateral premotor cortex (Brodmann area (BA) 6, 8; 16.6%), right orbitofrontal cortex (BA 10, 15.1%), bilateral temporal cortex (BA 20, 38; 15.9%), left thalamus (12.6%), and bilateral cerebellum (13.4%) as well as lower right cerebellar white matter volume (10.0%) relative to the comparison group at a corrected p<0.05 for multiple comparisons. Duration of cocaine use negatively correlated with right and left cerebellar gray matter volumes (r=−0.37, r=−0.39, respectively). In cocaine-dependent subjects, lower cerebellar hemispheric gray and white matter volumes were correlated with deficits in executive function and decreased motor performance. This study reports that cocaine-dependent subjects have lower gray matter volumes in cerebellar hemispheres as well as in frontal, temporal cortex, and thalamus. These findings are the first to suggest that the cerebellum may be vulnerable to cocaine-associated brain volume changes, and that cerebellar deficits may contribute to neuropsychological deficits and motor dysfunction frequently observed in cocaine-dependent subjects.Neuropsychopharmacology (2007) 32, 2229–2237; doi:10.1038/sj.npp.1301346; published online 14 February 2007
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Effects of Perimeter to Core Connectivity on Tall Building Behavior
Besjak, Charles,Biswas, Preetam,Petrov, Georgi I.,Streeter, Matthew,Devin, Austin Council on Tall Building and Urban Habitat Korea 2017 International journal of high-rise buildings Vol.6 No.1
The Pertamina Energy Tower (PET) and Manhattan West North Tower (MWNT) are two supertall towers recently designed and engineered by Skidmore, Owings & Merrill (SOM). The structural system for both buildings consists of an interior reinforced concrete core and a perimeter moment frame system, which is primarily structural steel. As is typical for tall towers with both concrete and steel elements, staged construction analysis was performed in order to account for the long term effects of creep and shrinkage, which result in differential shortening between the interior concrete core and steel perimeter frame. The particular design of each tower represents two extremes of behavior; PET has a robust connection between the perimeter and core in the form of three sets of outriggers, while the perimeter columns of MWNT do not reach the ground, but are transferred to the core above the base. This paper will present a comparison of the techniques used during the analysis and construction stages of the design process with the goal of understanding the differences in structural behavior of these two building systems in response to the long term effects of creep and shrinkage. This paper will also discuss the design and construction techniques implemented in order to minimize the differential shortening between the interior and exterior over the lifespan of these towers.
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