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Pandurangan, Ashok Kumar,Periasamy, Srinivasan,Anandasadagopan, Suresh Kumar,Ganapasam, Sudhandiran,Srinivasalu, Shyamala Devi Chennam Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
4-Nitroquinoline 1-oxide (4-NQO) a potent oral carcinogen, widely used for induction of oral carcinogenesis, has been found to induce lipid peroxidation in vivo and in vitro. Green tea contains a high content of polyphenols, which are potent antioxidants. Thus green tea polyphenols (GTP) might be expected play a protective role against 4-NQO induced lipid peroxidation and bone marrow toxicity. In the present study, a dose of 200 mg of GTP/kg b.wt/day was given orally for a week, simultaneously animals received 0.2 ml of 0.5% 4-NQO in propylene glycol (5 mg/ml) injected intramuscularly for three times/week. Oxidants and antioxidants such as malendialdehyde (MDA) and thiols, glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD) and catalase (CAT) were significantly decreased in 4-NQO induced animals except MDA, and these parameters were brought back to near normalcy on treatment with GTP. The results suggest that GTP treatment offers significant protection against 4-NQO induced lipid peroxidation and bone marrow toxicity and might be a promising potential candidate for prevention of mutations leading to cancer.
Modi, Hitesh N.,Hong, Jae-Young,Mehta, Satyen S.,Srinivasalu, S,Suh, Seung-Woo,Yi, Ju-Won,Yang, Jae-Hyuk,Song, Hae-Ryong Lippincott Williams Wilkins, Inc. 2009 1528-1159) Vol.34 No.11
STUDY DESIGN.: It is a retrospective study of 52 neuromuscular scoliosis patients with cerebral palsy (CP). OBJECTIVE.: To determine the effectiveness and amount of correction using posterior-only pedicle screw construct. SUMMARY OF BACKGROUND DATA.: Although there have been many reports in literature supporting the use of pedicle screw-only constructs for the correction of adolescent idiopathic scoliosis, similar studies have not been reported in patients with CP. METHODS.: We retrospectively evaluated outcomes of 52 neuropathic scoliosis patients (28 males and 24 females) with CP over minimum 2 years of follow-up. All patients underwent pedicle screw fixation without any anterior procedure for the correction. Pelvic fixation was done in 10 patients who had pelvis obliquity more than 15°. All coronal and sagittal parameters were noted after surgery and at final follow-up. Patient’s functional outcome was measured using modified Rancho Los Amigos Hospital system criteria. Complications were recorded from record sheets and any change in the ambulatory status was also recorded. RESULTS.: Mean age was 22 years at the time of operation and average follow-up was 36.1 month. Cobb’s angle was improved to 62.9% (P < 0.0001) from 76.8° to 30.1° after surgery and 31.5° at final follow-up. This correction of scoliosis (41%∼92%) was found to be statistically significant (P < 0.0001). Overall correction in pelvic obliquity was 56.2% from 9.2° before surgery to 4.0° after surgery which was 43.1% at final follow-up to 5.2°. Twenty-one patients (42%) improved their functional ability by grade 1 with 2 patients by grade 2. After the operation parent or caretakers of patients exhibited better sitting balance and nursing care. There were 32% complications in the series major being pulmonary. There were 2 perioperative deaths and 1 patient developed neurologic deficit due to screw impingement in canal, which was resolved after removal. CONCLUSION.: We reported satisfactory coronal and sagittal correction with posterior-only pedicle screw fixation without higher complication rate in CP patients. Further long-term study is recommended to evaluate the success of pedicle screw in this population.