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Son Ye Seul,Kwon Mijin,Son Naeun,Kim Sang-Kyu,Son Mi-Young 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.10
To exert their beneficial effects, it is essential for the commensal bacteria of probiotic supplements to be sufficiently protected as they pass through the low pH environment of the stomach, and effectively colonize the intestinal epithelium downstream. Here, we investigated the effect of a multilayer coating containing red ginseng dietary fiber, on the acid tolerance, and the adhesion and proliferation capacities of three Lactobacillus strains (Limosilactobacillus reuteri KGC1901, Lacticaseibacillus casei KGC1201, Limosilactobacillus fermentum KGC1601) isolated from Panax ginseng, using HT-29 cells, mucin-coated plates, and human pluripotent stem cell-derived intestinal epithelial cells as in vitro models of human gut physiology. We observed that the multilayer-coated strains displayed improved survival rates after passage through gastric juice, as well as high adhesion and proliferation capacities within the various gut epithelial systems tested, compared to their uncoated counterparts. Our findings demonstrated that the multilayer coat effectively protected commensal microbiota and led to improved adhesion and colonization of intestinal epithelial cells, and consequently to higher probiotic efficacy.
DASH 환경에서 ANFIS 구조를 이용한 비디오 품질 조절 기법
손예슬(Ye-Seul Son),김현준(Hyun-Jun Kim),김준태(Joon-Tae Kim) 한국방송·미디어공학회 2018 방송공학회논문지 Vol.23 No.1
Recently, as HTTP-based video streaming traffic continues to increase, Dynamic Adaptive Streaming over HTTP(DASH), which is one of the HTTP-based adaptive streaming(HAS) technologies, is receiving attention. Accordingly, many video quality control techniques have been proposed to provide a high quality of experience(QoE) to clients in a DASH environment. In this paper, we propose a new quality control method using ANFIS(Adaptive Network based Fuzzy Inference System) which is one of the neuro-fuzzy system structure. By using ANFIS, the proposed scheme can find fuzzy parameters that selects the appropriate segment bitrate for clients. Also, considering the characteristic of VBR video, the next segment download time can be more accurately predicted using the actual size of the segment. And, by using this, it adjusts video quality appropriately in the time-varying network. In the simulation using NS-3, we show that the proposed scheme shows higher average segment bitrate and lower number of bitrate-switching than the existing methods and provides improved QoE to the clients.
Son Hwan Choi,Hwa Joung Seo,Ye Seul Kim 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.12
This study is an analysis of the research trends of the Korean Journal of Educational Research, the leading journal in the study of Korean education. In this paper, the semantic network analysis method that applies to social network analysis was used to measure the frequency of certain types of research themes in order to examine their connection centrality and network diagram. This paper examined 355 theses published from 2006 to 2015. The results of the analysis revealed that the keyword "academic achievement" appeared most frequently (34 times), followed by “self-efficacy,” (24) “learner,” (17) “curriculum,” (16) “education,” (14) “teaching and learning,” (13) and “multicultural education.” (13) In the network diagram, the keywords of “learner,” “sense of efficacy,” “private education,” “academic achievement,” “assessment,” and “curriculum” demonstrated high centrality. Among these keywords, a network was formed centering around words such as “learner,” “assessment,” “academic achievement,” “sense of efficacy,” and “curriculum.” In other words, this indicates that these keywords are often associated with the research process. In this study, moreover, a network text cluster map with a wide variety was formed. This demonstrated that the Korean Journal of Educational Research covers a range of study contents of subcategories within the field of education. This paper examines the core themes of education, their connectivity and connection centrality, and a map of network clusters.
Genome-Wide Association Study of Bone Mineral Density in Korean Men
Bae, Ye Seul,Im, Sun-Wha,Kang, Mi So,Kim, Jin Hee,Lee, Soon Hang,Cho, Be Long,Park, Jin Ho,Nam, You-Seon,Son, Ho-Young,Yang, San Deok,Sung, Joohon,Oh, Kwang Ho,Yun, Jae Moon,Kim, Jong Il Korea Genome Organization 2016 Genomics & informatics Vol.14 No.2
Osteoporosis is a medical condition of global concern, with increasing incidence in both sexes. Bone mineral density (BMD), a highly heritable trait, has been proven a useful diagnostic factor in predicting fracture. Because medical information is lacking about male osteoporotic genetics, we conducted a genome-wide association study of BMD in Korean men. With 1,176 participants, we analyzed 4,414,664 single nucleotide polymorphisms (SNPs) after genomic imputation, and identified five SNPs and three loci correlated with bone density and strength. Multivariate linear regression models were applied to adjust for age and body mass index interference. Rs17124500 ($p=6.42{\times}10^{-7}$), rs34594869 ($p=6.53{\times}10^{-7}$) and rs17124504 ($p=6.53{\times}10^{-7}$) in 14q31.3 and rs140155614 ($p=8.64{\times}10^{-7}$) in 15q25.1 were significantly associated with lumbar spine BMD (LS-BMD), while rs111822233 ($p=6.35{\times}10^{-7}$) was linked with the femur total BMD (FT-BMD). Additionally, we analyzed the relationship between BMD and five genes previously identified in Korean men. Rs61382873 (p = 0.0009) in LRP5, rs9567003 (p = 0.0033) in TNFSF11 and rs9935828 (p = 0.0248) in FOXL1 were observed for LS-BMD. Furthermore, rs33997547 (p = 0.0057) in ZBTB and rs1664496 (p = 0.0012) in MEF2C were found to influence FT-BMD and rs61769193 (p = 0.0114) in ZBTB to influence femur neck BMD. We identified five SNPs and three genomic regions, associated with BMD. The significance of our results lies in the discovery of new loci, while also affirming a previously significant locus, as potential osteoporotic factors in the Korean male population.
명예슬 ( Ye Seul Myeong ),안수연 ( Soo Yeon Ahn ),손창규 ( Chang Gue Son ) 경락경혈학회 2016 Korean Journal of Acupuncture Vol.33 No.1
Objectives : This study aimed to overview the current education status of a traditional medicine by medical schools in Japan. Methods : We surveyed the literatures regarding a traditional medicine education in Japan, and get the information via email-interview with an officer of medical schools in Japan as well as from their websites. Results : Japan`s education ministry presented the appropriateness of education for traditional medicine to medical students in 2001, and most of medical schools begun to set up the classes in Japan. We received the detail information of the traditional medicine education from 21 medical schools. Nineteen colleges(approximately 90%) of those have the regular classes for traditional medicine while two colleges don`t have the education program for the traditional medicine. Most of medical schools have single class for introduction of traditional medicine, and have average 16.2±8.8 hours during the 4th grade(61.9%). Conclusions : We presented the general feature of education for traditional medicine in Japan, and this result would be basic information for an establishment of a strategy regarding the enhancement of national competitiveness of traditional Korean medicine.
자폐스펙트럼장애 아동의 사회적 상호작용 증진을 위한 동물매개중재의 치료적 효과에 대한 고찰
손지혜(Son, Ji-Hye),강소연(Kang, So-Yeon),강슬기(Kang, Seul-Gi),손유진(Son, Yu-Jin),정예진(Jong, Ye-Jin),최재향(Choi, Jae-Hyang) 한국정신보건작업치료학회 2021 한국정신보건작업치료학회지 Vol.8 No.1
목적 : 본 연구는 동물매개중재가 자폐스펙트럼장애 아동의 사회적 상호작용에 미치는 영향, 치료적 효과를 알아보고, 자료분석을 통해 얻은 정보를 동물매개중재에 관심을 가지고 있는 임상가와 작업치료사에게 기초 자료로 제공하고자 하였다. 연구방법 : 전자 데이터베이스인 RISS, Google Scholar, Korea Scholar를 사용하여 2007년 부터 2020년까지의 논문을 검색하였다. 주요 검색어는 ( 자폐스펙트럼장애 OR ASD OR Autism Spectrum Disorders ) AND ( 사회적 상호작용 OR 사회성 AND 동물매개중재 OR 반려견 OR Animal therapy OR Animal-assisted )를 사용하였다. 최종적으로 10편의 국내외 논문을 본 연구의 분석 대상으로 선정하였다. 선정된 논문은 저자/연도, 연구 목적, 대상자 N/ 나이, 기간/빈도, 중재 프로그램, 프로그램 제공자, 측정도구, 결과 순으로 정리하였다. 결과 : 중재 도우미 동물은 반려견, 기니피그, 말 3종류로 나타났다. 제공자는 동물매개심리상담사 8명을 포함하여 총 27명이며 지역사회 환경을 기반으로 프로그램이 진행됐다. 사용된 도구로는 사회성숙도검사(SMS)가 가장 많았다. 동물매개중재의 치료적 효과는 사회적 기술 향상에 가장 효과적이었고 다음으로 부정적 사회행동의 감소로 나타났다. 결론 : 본 연구는 동물매개중재 프로그램에 대한 체계적 고찰을 통하여 관련 영역을 확대하는 기초 자료를 마련하고자 하였다. 이는 추후 작업치료사가 동물매개중재(AAI) 전문가로서의 역할을 정립할 수 있는 후속연구를 계획하는 기초 자료로 활용되기를 기대한다. Objective : The aim of this systematic review is to investigate the effects of animal assisted interventions on social interaction and therapeutic effects to ASD, and provide the information obtained through data analysis as basic data to occupational therapists. Methods : Previous studies were found from an electronic database; RISS, Google Scholar, Korea Scholar database published between 2007 to 2020. The key terms were ASD OR Autism Spectrum Disorders AND Social interaction AND AAI OR Dog OR Animal therapy OR Animal-assisted . A total of 10 articles were used in this analysis. Results : Types of intervention included dogs, guinea pigs and horses. The provider was a total of 27 people, including 8 AAI experts, and the program was based on the community environment. The Social Maturity Scale(SMS) was the most used measurement tool. As the result of the intervention social skills were improved and negative social behaviors were decreased. Conclusion : This study was to provide basic data for expanding related areas through a systematic review of animal assisted interventions. In the future, the roles of occupational therapists should be clarified of animal assisted intervention and various animal assisted interventions should be made.