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RISS 인기검색어
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- 저자 : Soleiman Mahjoub (검색결과 2 건)
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Soleiman Mahjoub,Arezoo Ghadi,Roghayeh Pourbagher,Karimollah Hajian-Tilaki,Jila Masrour-Roudsari 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.4
Background and Purpose Regular exercise can result in changes in the levels of oxidative stress in the hippocampus; however, little attention has been paid to physical-activity-induced neuronal protection to exposure to lead compounds. This study investigated the effects of regular treadmill exercise on a DNA oxidative-damage marker [8-hydroxy-2’-deoxyguano¬sine (8-OHdG)] and the total antioxidant capacity (TAC) of hippocampal tissue in lead-ace¬tate exposed rats. Methods This study investigated the effects of 8 weeks of regular treadmill exercise on 8-OHdG and the TAC of hippocampal tissue in lead-acetate-exposed rats. Wistar rats were randomly divided into four groups: baseline, sham (control), lead, and exercise+lead. The ex¬ercise program involved running on a treadmill with increasing intensity five times a week for 8 weeks. Animals in the lead and exercise+lead groups received lead acetate at 20 mg/kg body weight intraperitoneally three times weekly for 8 weeks. Animals in the sham group re¬ceived solvent (ethyl oleate) at 30 mg/kg body weight three times weekly for 8 weeks. TAC and 8-OHdG were measured by spectrophotometric and ELISA techniques, respectively. Data were analyzed by ANOVA and Tukey’s post-hoc test with a significance cutoff of p≤0.05. Results The level of 8-OHdG and the TAC were significantly higher and lower, respective¬ly, in the lead group than in the baseline and sham groups (p<0.01). However, the 8-OHdG level and TAC value in hippocampal tissue were significantly decreased and increased, re-spectively, in the exercise+lead group relative to the lead group (p<0.05). Conclusions The TAC of hippocampal tissue may be directly associated with neural protec¬tion mechanisms of exercise following lead acetate injection, and the beneficial effects of regular exercise in preventing hippocampal neuronal damage could be due to decreased hippocampal oxidative stress such as reflected by a lower 8-OHdG level and increased TAC.
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Abbass Ghanbari-Niaki,Ayoub Saeidi,Mehdi Ahmadian,Leila Gharahcholo,Nooshin Naghavi,Mohammad Fazelzadeh,Soleiman Mahjoub,Stephen Myers,Andrew Williams 한국한의학연구원 2018 Integrative Medicine Research Vol.7 No.1
Background: We examined the effect of antioxidant supplementation and exercise on irisin within postmenopausal women. Methods: Forty-eight participants (age: 55.7 ± 4.9 years; weight: 68.0 ± 6.3 kg; BMI 27.0 ± 2.7; mean ± SD) were randomized into four groups for the eight week intervention: control group (CG; n = 12), resistance training group (RTG; n = 12), supplementation with Zataria multiflora group (ZG; n = 12), or supplementation with Z. multiflora and resistance training group (ZRTG; n = 12). RTG and ZRTG performed circuit resistance training, and both ZG and ZRTG consumed 500 mg of Z. multiflora every day during the intervention. Blood samples were taken 48 hours before and after the intervention. Results: There was a significant difference in irisin at post-training, with greater levels in ZRTG compared to CG. A significant increase was noted for irisin at post-training compared to pre-training for ZG, RTG, and ZRTG. Moreover, we identified a significant decrease in malondialdehyde in the RTG and ZRTG groups and increase in glutathione in the ZG, RTG, and ZRTG groups when compared to CG. Conclusion: These findings showed that exercise, Z. multiflora supplementation or their combination led to an increase in irisin.
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