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다량의 골양물질을 형성한 중심성 거대세포육아종의 영상진단
이설미,허민석,이삼선,최순철,박태원 대한구강악안면방사선학회 2000 Imaging Science in Dentistry Vol.30 No.2
A 19-year-old man was referred to Seoul National University Dental Hospital for evaluation of a large painless swelling of the left mandibular angle area in August, 1999. The growth had been first noted 6 years ago. He had visited other hospital in 1997. In spite of the treatment given at the hospital, the mass continued to grow rapidly. Conventional radiographs in 1999 showed an expansile, lobulated, and destructive lesion of the left mandibular body. CT scan demonstrated an expansile mass with a corticated margin. Bony septa were seen within the lesion. Internal calcification noted on the bone-setting CT image, and corresponded to the hypointense area in T1-weighted MRI image. MRI clearly delineated the extent of the lesion which had heterogenous intermediate signal intensity in T1-weighted images and heterogenous hyperintense signal intensity in T2-weighted images. The lesion was well-enhanced. Histopathologically, the lesion was well demarcated. Multinucleated giant cells were presented in a fibrous background, demonstrating a storiform pattern. Areas of osteoid rimmed by a few osteoblasts were scattered throughout the lesion. Inflammatory cells, blood vessels, and hemosiderin deposition were also shown. CGCG may show lots of internal calcification foci on the CT, and varied signal intensity in MRI. More cases will be needed to understand the features of the CT & MR fonding of CGCG. (Korean J Oral Maxillofac Radiol 2000 ; 30 : 127-131)
Orostachys japonicus DW and EtOH Extracts Induce Apoptosis in Cholangiocarcinoma Cell Line SNU-1079
Choi, Eun Sol,Lee, Jang Hoon The Society of Korean Medicine 2015 대한한의학회지 Vol.36 No.4
Objectives: This study was performed to investigate the anti-tumor effect of O. japonicus extracts on intrahepatic cholangiocarcinoma cell line SNU-1079. Methods: Cholangiocarcinoma SNU-1079 cells were treated with various concentrations of O. japonicus DW and EtOH extracts ($0-300{\mu}g/ml$) for 24, 48 or 72 h. Cell viability was evaluated through a PMS/MTS assay, and the apoptosis rate was examined through ELISA assay and flow cytometry analysis. The mRNA expression of apoptosis- and cell cycle progression-related genes (Bcl-2, Mcl-1, Bax, Survivin, Cyclin D1, and p21) was evaluated using real-time PCR, and the caspase activity was examined using immunoblot analysis. Results: O. japonicus extracts inhibited cell proliferation and increased apoptosis rate in both ELISA assay and flow cytometry analysis. O. japonicus extracts decreased Bcl-2, Mcl-1, Survivin, and Cyclin D1 mRNA expression and increased Bax mRNA level. O. japonicus extracts also increased Caspase-3 activation. Overall, O. japonicus DW extracts were more effective than EtOH extracts. Conclusions: O. japonicus inhibited cell proliferation and induced apoptosis in SNU-1079 cells via mitochondria -mediated intrinsic pathway, which leads to Caspase-3 activation. The results indicate that O. japonicus is a potential therapeutic herb with anti-tumor effect against intrahepatic cholangiocarcinoma.
Performance and potential appraisal of various microalgae as direct combustion fuel
Choi, Hong Il,Lee, Jeong Seop,Choi, Jin Won,Shin, Ye Sol,Sung, Young Joon,Hong, Min Eui,Kwak, Ho Seok,Kim, Chan Young,Sim, Sang Jun Elsevier 2019 Bioresource technology Vol.273 No.-
<P><B>Abstract</B></P> <P>Direct combustion of biomass is considered the most effective and simple means to contribute to CO<SUB>2</SUB> reduction. In this context, the life-cycle potential of microalgal solid fuel, which has been overlooked so far, was comprehensively scrutinized ranging from cultivation to direct combustion. According to the quantitative data, using the raw fuel was confirmed to offer great benefits over the conventional lipid-targeted microalgal fuel systems through exploiting all of the biomass’ energy potential, thereby being able to significantly increase the energy yield from biomass. The solid fuel is shown to exhibit diverse positive aspects owing to its remarkable calorific value, productivity and CO<SUB>2</SUB> fixation ability. The combustion test reveals coal-microalgae co-combustion brings beneficial consequences on combustibility and environmental impacts with no notable thermal efficiency drop. This holistic appraisal shows microalgae patently possess high potential as a direct combustion fuel, even outperforming that of extensively used woody fuels.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Direct combustion realizes the full potential energy yield from microalgal biomass. </LI> <LI> Microalgae’s oleaginous property contributes to their high calorific values. </LI> <LI> Their high carbon content increases the energy density and CO<SUB>2</SUB> reduction effects. </LI> <LI> Synergistic effects of coal-microalgae co-firing were quantitatively confirmed. </LI> <LI> The solid fuel shows better performance than woody biomass in various properties. </LI> </UL> </P>
Unilateral Multifocal Type 2 Papillary Renal Cell Carcinoma in Adolescence. A Case Report
Sol Yoon(윤솔),Jae Hwi Choi(최재휘),Sin Woo Lee(이신우),Seong Uk Jeh(제성욱),Jeong Seok Hwa(화정석),Jae Seog Hyun(현재석),Ky Hyun Chung(정기현),Hyun Oh Park(박현오),Jong Sil Lee(이종실),See Min Choi(최세민) 대한비뇨기종양학회 2019 대한비뇨기종양학회지 Vol.17 No.1
Papillary renal cell carcinomas (RCCs) can be classified into 2 subtypes (types 1 and 2), depending on their characteristic cytogenetics, immunostaining profiles, and gene-expression profiles. Compared with type 1 papillary RCCs, type 2 papillary RCCs are relatively rare and show more aggressive features. For those reasons, they are associated with a worse prognosis. A 13-year-old patient was admitted to the hospital with right kidney mass. A laparoscopic radical nephrectomy was performed, and results of the histopathologic examination confirmed it to be type 2 papillary RCC. Type 2 papillary RCCs are rarely found in unilateral and multifocal forms, especially in adolescence. Here, we report the unique case of papillary RCC at a young age.
Sol-lim Choi,Hyun-Sung Kim,Jae-Hwan Choi,Eun Hye Oh 대한평형의학회 2022 Research in Vestibular Science Vol.21 No.4
Objectives: This study aimed to investigate clinical significance of a head-bending test in benign paroxysmal positional vertigo (BPPV) involving the posterior semi-circular canal (PC-BPPV). Methods: We retrospectively recruited 256 patients with unilateral PC-BPPV between January 2016 and December 2021, and assessed the clinical characteri-stics of patients showing head-bending nystagmus (HBN). Results: Of 256 patients, 138 (53.9%) showed HBN. Most patients (n=136, 98.6%) had downbeat nystagmus with (n=38) or without (n=98) torsional component. The remaining two patients had pure upbeat and torsional nystagmus, respectively. The torsional component was directed to the contralesional side in all. Between patients with and without HBN, there were no significant differences in clinical characteristics such as age, lateralization, types of BPPV (canalolithiasis or cupulo-lithiasis), and success rate of repositioning maneuver. Conclusions: Head-bending test may be useful in predicting the diagnosis and lateralization of PC-BPPV.