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Bei Zhang,Siqi Han,Bing Feng,Xiaoyuan Chu,Longbang Chen,Rui Wang 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Hepatitis B virus (HBV) has an important role in the development of human hepatocellular carcinoma (HCC). Accumulated evidence has shown that HBV-encoded X protein (HBx) can induce both genetic alterations in tumor suppressor genes and oncogenes, as well as epigenetic aberrations in HCC pathogens. Non-coding RNAs (ncRNAs) mainly include microRNAs and long non-coding RNAs (lncRNAs). Although ncRNAs cannot code proteins, growing evidence has shown that they have various important biological functions in cell proliferation, cell cycle control, anti-apoptosis, epithelial–mesenchymal transition, tumor invasion and metastasis. This review summarizes the current knowledge regarding the mechanisms and emerging roles of ncRNAs in the pathogenesis of HBV-related HCC. Accumulated data have shown that ncRNAs regulated by HBx have a crucial role in HBV-associated hepatocarcinogenesis. The findings of these studies will contribute to more clinical applications of HBV-related ncRNAs as potential diagnostic markers or as molecular therapeutic targets to prevent and treat HBV-related HCC.
Xinyu Zhu,Xiao Liang,Kaiyue Gong,Xu Peng,Jun Cai,Xiaohan Liu,Chao Zhou,Siqi An,Chao Wu,Pengcheng Han 전력전자학회 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.12
As a vital component of power electronic transformers (PET), the reliability of a cascaded H-bridge rectifier (CHBR) is essential. Therefore, in this paper, a DC-port voltage balance strategy considering DC-port failure is researched to ensure the stable operation of a CHBR. However, if the DC-port voltage balance strategy is adopted to realize the single-phase balance of a CHBR, the three-phase currents become unbalanced. This paper uses a negative sequence control (NSC) strategy that is conducive to balancing DC-port voltage to achieve three-phase current balance. For the DC-port voltage balance, the matrix generation modulation (MGM) algorithm is proposed. In addition, the DC-port voltage balance boundary is analyzed to determine the range of the DC-port voltage balance in the CHBR. A 3-module cascading topology is adopted to demonstrate the MGM algorithm and the NSC strategy. Through experiments, results show the correctness and feasibility of the proposed strategy.