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RISS 인기검색어
- 검색키워드
- 저자 : Shridhar Narayan (검색결과 3 건)
- 무료
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Kakade, Aniket Narayan,Joshi, Sanjay S.,Naik, Charudatta Shridhar,Mhatre, Bhupendra Vilas,Ansari, Arsalan The Korean Dental Society of Anesthsiology 2021 Journal of Dental Anesthesia and Pain Medicine Vol.21 No.5
Background: Lignocaine with adrenaline is routinely used as a local anesthetic for dental procedures. Adrenaline was added to increase the duration of anesthesia. However, epinephrine containing a local anesthetic solution is not recommended in conditions such as advanced cardiovascular diseases and hyperthyroidism. Recently, ropivacaine has gained popularity as a long-acting anesthetic with superior outcomes. The goal of this study was to assess and compare the effectiveness of 0.75% ropivacaine alone and 2% lignocaine with adrenaline (1:80,000) in the removal of bilateral maxillary wisdom teeth using the posterior superior alveolar nerve block technique. Methods: This was a single-blind, randomized, split-mouth, prospective study assessing 15 systemically sound outpatients who needed bilateral removal of maxillary third molars. We randomly allocated the sides and sequences of ropivacaine and lignocaine with adrenaline administration. We evaluated the efficacy of both anesthetics with regard to the onset of anesthesia, intensity of pain, variation in heart rate, and blood pressure. Results: The onset of anesthesia was faster with lignocaine (138 s) than with ropivacaine (168 s), with insignificant differences (p = 0.001). There was no need for additional local anesthetics in the ropivacaine group, while in the lignocaine with adrenaline group, 2 (13.3%) patients required additional anesthesia. Adequate intraoperative anesthesia was provided by ropivacaine and lignocaine solutions. No significant difference was observed in the perioperative variation in blood pressure and heart rate. Conclusion: Ropivacaine (0.75%) is a safe and an adrenaline-free local anesthetic option for posterior superior alveolar nerve block, which provides adequate intraoperative anesthesia and a stable hemodynamic profile for the removal of the maxillary third molar.
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Remating in a Drosophilid : Phorticella striata
Yenisetti, Sharat Chandra,Hegde, Shridhar Narayan 한국유전학회 2002 Genes & Genomics Vol.24 No.2
Remating is common in males and females of many species of Drosophila. Reproductive success in male organisms is limited by the number of females he can inseminate and the ability to produce more eggs in case of females. The phenomenon of remating by females is a prerequisite for the occurrence of sperm competition between males. Phorticella striata is a drosophilid insect discovered from Karnataka, India. Male and female remating were observed in two mass culture stocks raised from flies collected from Mysore and Ahmadabad. Study revealed that in male Phorticella variation in remating frequency, mean matings between two populations was insignificant. Variation in mating durations for different matings in both the strains was also insignificant. However, significant inter-strain mating duration variations for the first four coatings were observed. Variation in female remating latency between the populations was found statistically insignificant. Insignificant variation was observed for the duration of copulation between the first and second matings in Mysore population. However, remating duration was significantly shorter in Ahmadabad population. Observed inter-strain variations can be attributed to geographic isolation which may lead to 'response variation' of the genetic system of a species to different physical environments.
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Nagaraj M. Kulkarni,Milind M. Muley,Mallikarjun S. Jaji,G. Vijaykanth,J. Raghul,Neetin Kumar D. Reddy,Santosh L. Vishwakarma,Navin B. Rajesh,Jeyamurugan Mookkan,Uma Maheswari Krishnan,Shridhar Narayan 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
Atorvastatin is a 3-hydroxy-3-methylglutarylcoenzyme-A reductase inhibitor used in the treatment ofatherosclerosis and dyslipidemia. Studies have evaluatedthe utility of statins in the treatment of skin inflammationbut with varied results. In the present study, we investigatedthe effect of atorvastatin on TNF-a release andkeratinocyte proliferation in vitro and in acute and chronic12-O-tetradecanoylphorbol-13-acetate (TPA) induced skininflammation in vivo. Atorvastatin significantly inhibitedlipopolysacharide induced TNF-a release in THP-1 cellsand keratinocyte proliferation in HaCaT cells. In an acutestudy, topical atorvastatin showed dose dependent reductionin TPA induced skin inflammation with highest efficacyobserved at 500 lg/ear dose. In chronic study, topicalatorvastatin significantly reduced TPA induced ear thickness,ear weight, cutaneous cytokines, MPO activity andimproved histopathological features comparable to that ofdexamethasone. Atorvastatin also inhibited TPA stimulatedNF-jB activation in mouse ear. In conclusion, our resultssuggest that atorvastatin ameliorates TPA induced skininflammation in mice at least in part, due to inhibition ofcytokine release and NF-jB activation and may be beneficialfor the treatment skin inflammation like psoriasis.
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