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Shawali, Ahmad S.,Salkaabi, harifia S.,Abdallah, Magda A. The Pharmaceutical Society of Korea 1991 Archives of Pharmacal Research Vol.14 No.3
The tautomerism in 3-phenyl-4-arylazo-5-isoxazolones 1 was examined by $^1H-NMR$ spectra of $^15N-labeled$ compound and by HMO method. Both spectra data $(^1H-NMR\;and\;IR)$ and bonding energies are in support of the assignment of the hydrazone structure to such compounds. It is further shown that intermolecular and intramolecular hydrogen bondings favor the hydrazone tautomer.
Synthesis and Cycloaddition Reactions of N-Aryl-2-furohydrazonyl Chlorides
S, Shawali-Ahmad,M, Hassaneen-Hamdi,A, Ibrahim-Hossin The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.2
The novel N-phenyl-2-furohydrazonyl chloride 4A and its p-nitro analog 4B have been prepared and identified. The cycloaddition reactions of nitrilimines 5A and 5B, derived by base catalyzed dehydrochlorination of 4A and 4B respectively, to a variety of dipolarophiles were investigated. The results showed that 4A and 4B are usuful precursors for synthesis of differently substituted 3-(2-furyl)-2-pyrazoline derivatives and their pyrazoles and analogs.
Ahmad Sami Shawali,Thoraya A. Farghaly,Shadia M. Hussein,Mohamed M. Abdalla 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.6
Reactions of hydrazonoyl halides with cyanoacetichydrazide and its N-arylidene derivatives proceededsite-selectively and afforded the respective pyrazolo[3,4-d]pyridazine and aldehyde N-(1-aryl-3-acetyl-4-cyanopyrazol-5-yl)hydrazone derivatives. The structures of theproducts were elucidated on the basis of their spectral andelemental analyses. The anti-aggressive activity of thecompounds prepared was screened.
Ahmad S. Shawali,Sherif M. Sherif,Manal A. A. Darwish,Mahmoud M. El-merzabani 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.1
A new series of 3-(1,3-disubstituted-1H-pyrazole-4-carbonyl)-1,7-diphenyl-[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones 4 was prepared by reaction of the enaminone 2 with hydrazonoyl halides 3. The preliminary screening for antitumor activity of the synthesized compounds was carried out against Ehrlich Ascites Carcinoma tumor cells. The results revealed that the studied compounds 4 have low or no antitumor activity towards EAC tumor cells.
Novel Facile Synthesis of Imidazo[1,2-b]-[1,2,4,5]tetrazines with Potential Antimicrobial Activity
Ahmad Sami Shawali,Nagla M. Tawfik 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.7
Starting from 1-amino-2-methylthio-4-phenylimidazole 2, a series of the title compounds have been synthesized via its reactions with various hydrazonoyl halides 3. The mechanism of the reactions studied is discussed. The structure of the compounds prepared were elucidated on the basis of their elemental analyses, spectral data and alternate synthesis. The antimicrobial activities of the compounds prepared were screened and the results showed that most of such compounds exhibit considerable activities.
Synthesis and Cycloaddition Reaction of C-(2-naphthoyl)-N-arylmethanohydrazonoylpyridinium Bromides
Hassaneen, Hamdi M.,Shawali, Ahmad S.,Elwan, Nehal M.,Abounada, Nada M.,Algharib, Mohammed S. The Pharmaceutical Society of Korea 1992 Archives of Pharmacal Research Vol.15 No.4
Coupling of naphthacylpyridinium bromide 2 [1-(2-naphthyl) ethanone-2-pyridinium bromide] with N-nitrosoacetarylamides afforded C-(2-naphthoyl)-N-arylmethanohydrazonoylpyridinium bromides 3A-C. Treatment of 3A-C with base afforded the corresponding tetrazines 6A-C. Cycloaddition of nitrilimines 5A-C to N-arylmaleimides, acrylonitrile, ethyl acrylate, acrylamide, fumaronitrile, $\alpha$-cyanocinnamonitriles, ethyl $\alpha$-cyano-p-nitrocinnamates and $\alpha$-cyano-p-nitrocinnamamide afforded the corresponding cycloadducts 7-14, respectively. The cycloadducts 11-14 undergo a facile thermal elimination of hydrogen cyanide to give the corresponding pyrazoles 18-21 respectively.
Hassaneen, Hamdi M.,Shawali, Ahmad S.,Elwan, Nehal M.,Ibrahim, Al Hossien A. The Pharmaceutical Society of Korea 1991 Archives of Pharmacal Research Vol.14 No.3
Synthesis of C-(2-furyl)-N-(4-nitrophenyl)methanohydrazonyl bromide 2 is described. Treatment of 2 with uncleophiles affords the corresponding substitution products 3-7. Also, compound 2 reacts with selenocyanate anion and thiocyanate anion and give the corresponding selenadiazoline and thiadiazoline 8 and 9, respectively. Moreover, reaction of 2 with enolates of various active methylene compounds afforded the pyrazole derivatives 17-20.