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RISS 인기검색어
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- 저자 : Selasi, G.N. (검색결과 2 건)
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Selasi, G.N.,Nicholas, A.,Jeon, H.,Lee, Y.C.,Yoo, J.R.,Heo, S.T.,Lee, J.C. Elsevier Science 2015 INFECTION GENETICS AND EVOLUTION Vol.36 No.-
This study investigated the genetic basis of antimicrobial resistance and the epidemiological characteristics of 125 carbapenem-resistant Acinetobacter baumannii (CRAB) isolates collected from 2011 to 2012 in a Korean hospital. All CRAB isolates showed an extensively drug-resistant phenotype, but were susceptible to tigecycline. The bla<SUB>OXA-23</SUB> and armA genes were mainly responsible for resistance to carbapenems and aminoglycosides, respectively. Four colistin-resistant CRAB isolates with different pulsotypes were identified. All four colistin-resistant isolates had a deletion at nucleotide 776 in lpxA, while one also had an insertion at nucleotide 732 in lpxA. All CRAB isolates belonged to three sequence types (STs): ST191 (n=118), ST208 (n=6), and ST436 (n=1), but were classified into 33 arbitrary pulsotypes. Of the CRAB ST191 isolates, two main arbitrary pulsotypes 5 (n=20) and 18 (n=17) emerged sequentially, but were not clonally related to CRAB isolates collected from 2009 to 2010 in the same hospital. Furthermore, of the two main pulsotypes identified among CRAB ST191 isolates from 2009 to 2010, one was clonally related to sporadic CRAB ST191 isolates from 2011 to 2012, but the other was not related to any CRAB isolate from 2011 to 2012. In conclusion, this study shows the clonal dynamics of CRAB ST191 isolates in a Korean hospital during the last four years.
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Na, Seok Hyeon,Jeon, Hyejin,Kim, Yoo Jeong,Kwon, Hyo Il,Selasi, Gati Noble,Nicholas, Asiimwe,Yun, Chang-Soo,Lee, Sang Ho,Lee, Je Chul Elsevier 2017 International journal of antimicrobial agents Vol.49 No.1
<P><B>Abstract</B></P> <P>The aim of this study was to screen lead compounds exhibiting potent in vitro antimicrobial activity against multidrug-resistant (MDR) <I>Acinetobacter baumannii</I> strains from a library of chemical compounds. In a high-throughput screening analysis of 7520 compounds representative of 340,000 small molecules, two 4<I>H</I>-4-oxoquinolizine compounds were the most active against <I>A. baumannii</I> ATCC 17978. Subsequent selection and analysis of 70 4<I>H</I>-4-oxoquinolizine compounds revealed that the top 7 compounds were extremely active against extensively drug-resistant (XDR) <I>A. baumannii</I> isolates. These compounds commonly carried a 1-cyclopropyl-7-fluoro-4-oxo-4<I>H</I>-quinolizine-3-carboxylic acid core structure but had different C-8 and/or C-9 moieties. Minimum inhibitory concentrations (MICs) of the seven compounds against fluoroquinolone-resistant <I>A. baumannii</I> isolates were found to be in the range of 0.02–1.70 µg/mL regardless of the mutation types in the quinolone resistance-determining region (QRDR) of GyrA and ParC. Cytotoxicity of the seven compounds was observed in HeLa and U937 cells at a concentration of 50 µg/mL, which was >32.5- to 119-fold higher than the MIC<SUB>90</SUB> for <I>A. baumannii</I> isolates. In conclusion, novel 4<I>H</I>-4-oxoquinolizine compounds represent a promising scaffold on which to develop antimicrobial agents against drug-resistant <I>A. baumannii</I> strains.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Development of new antimicrobials for drug-resistant <I>Acinetobacter baumannii</I> is urgently needed. </LI> <LI> 4<I>H</I>-4-oxoquinolizines were screened against <I>A. baumannii</I> ATCC 17978 by HTS analysis. </LI> <LI> Novel 4<I>H</I>-4-oxoquinolizines were extremely active against XDR <I>A. baumannii</I> isolates. </LI> <LI> Novel 4<I>H</I>-4-oxoquinolizines were active against fluoroquinolone-resistant <I>A. baumannii</I>. </LI> </UL> </P>
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