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- 저자 : Sardeli, Chrysanthi (검색결과 2 건)
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Li, Chunling,Shi, Yimin,Wang, Weidong,Sardeli, Chrysanthi,Kwon, Tae-Hwan,Thomsen, Klaus,Jonassen, Thomas,Djurhuus, Jens Christian,Knepper, Mark A,Nielsen, Soren,Frokiaer, Jorgen American Physiological Society 2006 American Journal of Physiology Vol.290 No.2
<P>The purpose of this study was to evaluate the effects of the anti-inflammatory hormone alpha-melanocyte-stimulating hormone (alpha-MSH) treatment on renal function and expression of aquaporins (AQPs) and Na-K-ATPase in the kidney in response to 24 h of bilateral ureteral obstruction (BUO) or release of BUO (BUO-R). In rats with 24-h BUO, immunoblotting revealed that downregulation of AQP2 and AQP3 was attenuated (AQP2: 38 +/- 5 vs. 13 +/- 4%; AQP3: 44 +/- 3 vs. 19 +/- 4% of sham levels; P < 0.05), whereas downregulation of Na-K-ATPase was prevented by alpha-MSH treatment (Na-K-ATPase: 94 +/- 7 vs. 35 +/- 5% of sham levels; P < 0.05). Immunocytochemistry confirmed the changes in AQP1 and Na-K-ATPase expression. Renal tubular cell apoptosis was confirmed in BUO kidneys, and alpha-MSH treatment virtually completely abolished apoptosis. Furthermore, we measured glomerular filtration rate (GFR) and effective renal plasma flow (ERPF), respectively. Forty-eight hours after BUO-R demonstrated that alpha-MSH treatment almost completely prevented the decrease in GFR (nontreated: 271 +/- 50; alpha-MSH: 706 +/- 85; sham: 841 +/- 105 microl x min(-1).100 g body wt(-1), P < 0.05) and ERPF (nontreated: 1,139 +/- 217; alpha-MSH: 2,598 +/- 129; sham: 2,633 +/- 457 microl x min(-1).100 g body wt(-1), P < 0.05). alpha-MSH treatment also partly prevented the downregulation of AQP1 and Na-K-ATPase expression in rats after BUO-R for 48 h. In conclusion, alpha-MSH treatment significantly prevents impairment in renal function and also prevents downregulation of AQP2, AQP3, and Na-K-ATPase during BUO or AQP1 and Na-K-ATPase after BUO-R, demonstrating a marked renoprotective effect of alpha-MSH treatment in conditions with urinary tract obstruction.</P>
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Fabiano Camara,Stephen Berg,Brent Bradford,Sarah Hutchinson,Amanda Sardeli The Pacific Early Childhood Education Research Ass 2022 Asia-Pacific journal of research in early childhoo Vol.16 No.2
The aim of this study was to systematically review the protocols to assess the built environment in the context of early childhood and physical activity. Three databases were systematically searched for studies that examined associations between the built environment and preschoolers’ physical activity levels. A total of 27 studies were included in the analysis. Results show a clear distinction between approaches administered in the neighborhoods and childcare domains. Although Geographic Information Systems are employed in most studies in the neighborhood domain and have been understood as an objective approach, findings have indicated a lack of specificity regarding early childhood environmental variables, which can compromise protocols content validity. Further, although self-perceived approaches were found in only three studies, analysis of instrument content validity and cross-cultural adaptation also showed limited validation evidence. In the childcare context, the micro-scale built environment is a strong trend in customization of measurement protocols in early childhood. However, present findings have indicated the necessity for enhancements to validation procedures, particularly regarding internal consistency and content validity to develop needed customization. Therefore, future research should utilize more rigorous validation techniques to address the micro-scale built environment within the context of early childhood physical activity levels.
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