http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ko, Young San,Cho, Sung Jin,Park, Jinju,Kim, Younghoon,Choi, Yong Joon,Pyo, Jung-Soo,Jang, Bo Gun,Park, Jong-Wan,Kim, Woo Ho,Lee, Byung Lan Nature Publishing Group 2015 The British journal of cancer Vol. No.
<P><B>Background:</B></P><P>The biological significance of FOXO1, a member of the forkhead box O transcription factor family, in gastric cancer (GC) remains unclear. The present study provides direct evidence of the role of FOXO1 in tumour growth and metastasis of GC in relation to human epidermal growth factor receptor 2 (HER2).</P><P><B>Methods:</B></P><P>The expressions of FOXO1 and HER2 were modulated in GC cell lines (SNU-638, MKN45, SNU-216 and NCI-N87) by stable transfections. The effects of transfection on GC phenotypes were evaluated <I>in vitro</I> and in animal models. In addition, the relationship between FOXO1 and HER2 was analysed using GC clinical specimens, cell lines and xenografts.</P><P><B>Results:</B></P><P>FOXO1 silencing in GC cells increased colony formation and mesenchymal transition <I>in vitro</I>, as well as tumour growth and metastasis in nude mice, whereas HER2 silencing induced the opposite results.. Furthermore, an inverse relationship between FOXO1 and HER2 was found in clinical specimens of GC, GC cells and GC xenograft tumours. Although a negative crosstalk between these two molecules was shown, double knockdown of both FOXO1 and HER2 in GC cells revealed that HER2 silencing reversed the FOXO1 shRNA-induced migration and invasion even without the FOXO1 restoration.</P><P><B>Conclusions:</B></P><P>Our results indicate that loss of FOXO1 promotes GC growth and metastasis by upregulating HER2 expression and that the HER2 expression is more critical to the induction of GC cell metastasis. The present study provides evidence that the FOXO1/HER2 pathway may regulate GC progression in a subgroup of GC patients.</P>
Majority gate logic using current-induced magnetic domain wall motion
San Ko,Geun-Hee Lee,Byong-Guk Park,Kab-Jin Kim 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.1
Existing computing technology is based on von Neumann architecture which is composed of memory unit for storing information and processing unit for performing logic operation. As the memory and processor are physically separated, data transfer between them consumes a substantial energy and time, which is known as von Neuman bottleneck. One way to overcome this bottleneck is to combine the memory and processor in a single space. This so-called processor in memory (PiM) technology will improve the performance of computer dramatically [1]. In this presentation, we propose a majority gate logic that utilizes the current-induced magnetic domain walls (DWs) motion, which can directly be connected to the DW-based racetrack memory [2,3,4] to build PiM. We use cross-wire geometry having four discrete branches, of which three branches are inputs and the other branch is output, and demonstrate that the cross-wire performs as majority gate by using micromagnetic simulations. The DWs created at the input branches are moved by current-induced spin orbit torque [5,6] and are congregated at the cross, from which the majority of the inputs are ejected to the output branches. This majority gates operates as AND, OR, NAND, NOR logic operations by properly selecting the inputs. In addition to the simulation, we also experimentally verify the DW-based majority gate in Co/Pt microwires. The current-driven DW motion and its logic operation is successfully demonstrated in Co/Pt cross-wire, suggesting that the majority gate is experimentally achievable.
Structural Object Recognition Using Entropy Correspondence Measure of Line Features
KO, San,LEE, Kyoung Mu The Institute of Electronics, Information and Comm 2008 IEICE transactions on information and systems Vol.91 No.1
<P>In this paper we propose an efficient line feature-based 2D object recognition algorithm using a novel entropy correspondence measure (ECM) that encodes the probabilistic similarity between two line feature sets. Since the proposed ECM-based method uses the whole structural information of objects simultaneously for matching, it overcomes the common drawbacks of the conventional techniques that are based on feature to feature correspondence. Moreover, since ECM is endowed with probabilistic attribute, it shows quite robust performance in the noisy environment. In order to enhance the recognition performance and speed, line features are pre-clustered into several groups according to their inclination by an eigen analysis, and then ECM is applied to each corresponding group individually. Experimental results on real images demonstrate that the proposed algorithm has superior performance to those of the conventional algorithms in both the accuracy and the computational efficiency, in the noisy environment.</P>
Carpal Tunnel Syndrome in Elderly Patients
Young San Ko,Hee-Jin Yang,Sung Bae Park,Son Young-Je,Kang Min Kim,Lee Sang Hyung,Young Seob Chung 대한말초신경학회 2018 The Nerve Vol.4 No.2
Objective Carpal tunnel syndrome (CTS) is a common entrapment neuropathy. Differences in the clinical features and treatment outcomes of CTS between elderly and young patients remain debatable. We analyzed CTS in elderly patients to assess the differences in the characteristics of CTS between elderly and younger patients. Methods We retrospectively analyzed patients who were operated for CTS between January 2010 and December 2016. Patients were diagnosed based on clinical features and neurological findings and operated owing to persistent symptoms refractory to conservative management. Nerve conduction study (NCS) and ultrasonography were performed preoperatively. Endoscopic surgery was performed under local anesthesia. Carpal tunnel pressure (CTP) was measured intraoperatively using the Spiegelberg intracranial pressure monitoring device connected to a parenchymal type catheter. Results We performed 304 operations −48 wrists operated were in patients aged ≥70 years. No significant difference was observed in the sex distribution. The Elderly group showed more severe clinical symptoms (p=0.04), a higher frequency of thenar atrophy (p=0.02), NCS grades indicative of more severe disease (p=0.001), and more prominent median nerve swelling (p=0.04). Both groups showed similar CTPs before and after division of the transverse carpal ligament. Elderly patients showed poorer outcomes than those observed in younger patients (p=0.005). Conclusion Our series demonstrated that elderly patients showed more severe clinical features and findings using supplementary tests. Considering the lack of intergroup differences in CTP, we conclude that the reaction to compression of the median nerve in elderly patients causes more severe clinical, radiological, and electrodiagnostic features.
고산(San Ko),이근희(Geun-Hee Lee),김갑진(Kab-Jin Kim),박병국(Byong-Guk Park) 한국자기학회 2021 韓國磁氣學會誌 Vol.31 No.5
We propose a universal spintronic logic device based on the current-induced magnetic domain wall (DW) motion. The majority gating operation is demonstrated by micromagnetic simulation using spin-orbit torque (SOT)-driven DW motion in Hall bar structures with perpendicular magnetic anisotropy. The logic gates including AND, OR, NAND, NOR are demonstrated, indicating the universality of DW majority gate. The simulation is partially confirmed by experiment, in which we found that the asymmetry in DW motion induced by Dzyaloshinskii-Moriya interaction or local Oersted field can cause the device malfunction. Our result suggests that the DW motion can be used not only in memory device but also in logic device, which could be useful in future processing-in-memory computing technology.