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- 저자 : Rukmini Mridula Kandadai (검색결과 2 건)
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Association of Helicobacter pylori with Parkinson’s Disease
Kandadai Rukmini Mridula,Rupam Borgohain,Vupparalli Chandrasekhar Reddy,Venkata Chandrasekhar Srinivasarao Bandaru,Turaga Suryaprabha 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.2
Background and Purpose Parkinson’s disease (PD) is a major neurological disorder that requires lifelong treatment, and the combined presence of Helicobacter pylori (H. pylori) infection can increase the required anti-PD medications. We aim to investigate the effect of H. pylori infection in Indian PD patients. Methods We prospectively recruited 36 PD patients from December 2007 to January 2011. All patients underwent a detailed neurological evaluation and serological examination for H. pylori infection. Seropositive and seronegative patients were considered to be the cases and controls, respectively. All patients who were seropositive received triple therapy for 2 weeks. Outcome measures of the mean ‘off’ Unified Parkinson’s Disease Rating Scale (UPDRS)-III score, mean ‘on’ UPDRS-III score, mean onset time, mean ‘on’ duration, and mean daily ‘on’ time were measured at baseline and at a 3-week follow-up. Results H. pylori-IgG positivity was present in 18 (50%) PD patients. The prevalence of men (72.2% vs. 33.3%), mean duration of disease (13.8 vs. 12.5) and mean levodopa equivalent daily dose (824 mg vs. 707 mg) were significantly higher among H. pylori positive patients than in controls (p<0.0001). Controls had a significantly longer ‘on’ duration and daily ‘on’ time, and better ‘on’ UPDRS-III scores. Seropositive patients took a significantly longer time to turn ‘on’ after a levodopa challenge. At the 3-week follow-up, H. pylori eradication significantly improved the mean ‘on’ UPDRS-III score, onset time, ‘on’ duration, and daily ‘on’ time. Conclusions H. pylori infection was present in 50% of Indian PD patients. H. pylori seropositivity was associated with a poor response to levodopa and increased medication usage, while eradication therapy was associated with better patient outcomes.
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Rukmini Mridula Kandadai,Praveen Yada,Megha S. Uppin,Shaik Afshan Jabeen,Ajith Cherian,Meena Angamuthu Kanikannan,Rupam Borgohain,Sundaram Challa 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.4
Background Subacute sclerosing panencephalitis (SSPE) is a delayed and fatal manifestationof measles infection. Fulminant SSPE is a rare presentation in which the disease progresses todeath over a period of 6 months. The clinical features are atypical and can be misleading. Case Report We report herein a teenage boy who presented with acute-onset gait ataxia followed by right hemiparesis that evolved over 1 month, with left-hemispheric, delta-range slowing on the electroencephalogram (EEG). Magnetic resonance imaging disclosed multiple whitematter hyperintensities, suggesting a diagnosis of acute disseminated encephalomyelitis. Hereceived intravenous steroids, and within 4 days of hospital admission he developed unilateralslow myoclonic jerks. Repeat EEG revealed Rademecker complexes, pathognomonic of SSPE,and an elevated titer of IgG antimeasles antibodies was detected in his cerebrospinal fluid. Thedisease progressed rapidly and the patient succumbed within 15 days of hospitalization. The diagnosis of SSPE was confirmed by autopsy. Conclusions This case illustrates the difficulty of recognizing fulminant SSPE when it manifests with asymmetric clinical and EEG abnormalities.
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