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Ruiyue Qiu,Wen Zhao,Jiao Yang,Yanwei Shen,Biyuan Wang,Pan Li,Andi Zhao,Qi Tian,Mi Zhang,Min Yi,Jin Yang,Danfeng Dong 한국유방암학회 2019 Journal of breast cancer Vol.22 No.2
Purpose: Numerous previous studies have reported inconsistent results about the differences between synchronous contralateral breast cancer (sCBC) and metachronous contralateral breast cancer (mCBC). This study aimed to compare the clinical characteristics and outcomes between sCBC and mCBC and determine predictive factors for the survival of sCBC and mCBC patients. Methods: Using the Surveillance, Epidemiology, and End Results Program database, we identified sCBC or mCBC patients from 2000 to 2010. The Kaplan-Meier method and Cox proportional hazards regression analysis were used to analyze overall survival and breast cancer-specific survival (BCSS) rates of sCBCs and mCBCs, respectively. Results: Overall, 14,057 sCBC (n = 8,139, 57.9%) and mCBC (n = 5,918, 42.1%) patients were included. The first tumors of sCBC were more likely to have higher stage and more lymph and distant metastases, whereas those of mCBC were more often infiltrating ductal carcinoma (IDC), had localized stage, were estrogen receptor (ER) and progesterone receptor (PR) negative, and had less axillary nodal involvement. The second tumors of mCBC tended to be IDC and have higher grade, adverse stage, ER and PR-negativity; and more axillary nodal involvement, compared to the second tumors of sCBC. mCBC patients had significantly favorable 5-year BCSS but worse long-term BCSS compared with sCBC patients. Moreover, subgroup analysis revealed no significant difference of BCSS between sCBC and mCBC among patients aged 18–60 years. Multivariate analysis indicated that age, grade, and stage of 2 tumors; surgery for second tumor; and ER status of the second tumor were independent prognostic factors for BCSS of contralateral breast cancer (CBC). Conclusion: The characteristics and outcomes of sCBCs and mCBCs were substantially different. sCBC and mCBC patients may have different prognosis, and the prognosis of CBC depends on the first and second tumors.
SEINA: A two-dimensional steam explosion integrated analysis code
Wu Liangpeng,Sun Ruiyu,Chen Ronghua,Tian Wenxi,Qiu Suizheng,Su G.H. 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.10
In the event of a severe accident, the reactor core may melt due to insufficient cooling. the hightemperature core melt will have a strong interaction (FCI) with the coolant, which may lead to steam explosion. Steam explosion would pose a serious threat to the safety of the reactors. Therefore, the study of steam explosion is of great significance to the assessment of severe accidents in nuclear reactors. This research focuses on the development of a two-dimensional steam explosion integrated analysis code called SEINA. Based on the semi-implicit Euler scheme, the three-phase field was considered in this code. Besides, the influence of evaporation drag of melt and the influence of solidified shell during the process of melt droplet fragmentation were also considered. The code was simulated and validated by FARO L-14 and KROTOS KS-2 experiments. The calculation results of SEINA code are in good agreement with the experimental results, and the results show that if the effects of evaporation drag and melt solidification shell are considered, the FCI process can be described more accurately. Therefore, it is proved that SEINA has the potential to be a powerful and effective tool for the analysis of steam explosions in nuclear reactors.