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- 저자 : Rosenblum, Sahar (검색결과 5 건)
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The Role of Protein Phosphorylation in the Gustatory Cortex and Amygdala During Taste Learning
Kobi Rosenblum,Chinnakkaruppan Adaikkan 한국뇌신경과학회 2012 Experimental Neurobiology Vol.21 No.2
Protein phosphorylation and dephosphorylation form a major post-translation mechanism that enables a given cell to respond to ever-changing internal and external environments. Neurons, similarly to any other cells, use protein phosphorylation/dephosphorylation to maintain an internal homeostasis, but they also use it for updating the state of synaptic and intrinsic properties, following activation by neurotransmitters and growth factors. In the present review we focus on the roles of several families of kinases, phosphatases, and other synaptic-plasticity-related proteins, which activate membrane receptors and various intracellular signals to promote transcription, translation and protein degradation, and to regulate the appropriate cellular proteomes required for taste memory acquisition, consolidation and maintenance. Attention is especially focused on the protein phosphorylation state in two forebrain areas that are necessary for taste-memory learning and retrieval:the insular cortex and the amygdala.Th e various temporal phases of taste learning require the activation of appropriate waves of biochemical signals.Th ese include: extracellular signal regulated kinase I and II (ERKI/II) signal transduction pathways; Ca2+-dependent pathways;tyrosine kinase/phosphatase-dependent pathways; brain-derived neurotrophicfactor (BDNF)-dependent pathways; cAMP-responsive element bindingprotein (CREB); and translation-regulation factors, such as initiation and elongation factors,and the mammalian target of rapamycin (mTOR). Interestingly, coding of hedonic and aversive taste information in the forebrain requires activation of diff erent signal transduction pathways.
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Mi Lu,Lisa Brenzinger,Lisa Rosenblum,Matthew Salanitro,Ingo Fietze,Martin Glos,Giuseppe Fico,Thomas Penzel 대한의용생체공학회 2023 Biomedical Engineering Letters (BMEL) Vol.13 No.3
We aim to evaluate the diagnostic performance of the SleepImage Ring device in identifying obstructive sleep apnea(OSA) across different severity in comparison to standard polysomnography (PSG). Methods Thirty-nine patients (mean age,56.8 ± 15.0 years; 29 [74.3%] males) were measured with the SleepImage Ring and PSG study simultaneously in order toevaluate the diagnostic performance of the SleepImage device for diagnosing OSA. Variables such as sensitivity, specificity,positive and negative likelihood ratio, positive and negative predictive value, and accuracy were calculated with PSG-AHIthresholds of 5, 15, and 30 events/h. Receiver operating characteristic curves were also built according to the above PSGAHIthresholds. In addition, we analyzed the correlation and agreement between the apnea-hypopnea index (AHI) obtainedfrom the two measurement devices. Results There was a strong correlation (r = 0.89, P < 0.001 and high agreement in AHIbetween the SleepImage Ring and standard PSG. Also, the SleepImage Ring showed reliable diagnostic capability, with areasunder the receiver operating characteristic curve of 1.00 (95% CI, 0.91, 1.00), 0.90 (95% CI, 0.77, 0.97), and 0.98 (95% CI,0.88, 1.000) for corresponding PSG-AHI of 5, 15 and 30 events/h, respectively. Conclusion The SleepImage Ring could bea clinically reliable and cheaper alternative to the gold standard PSG when aiming to diagnose OSA in adults.
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Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease
Gregory Vurture,Benoit Peyronnet,Jose-Alberto Palma,Rachael D. Sussman,Dominique R. Malacarne,Andrew Feigin,Ricardo Palmerola,Nirit Rosenblum,Steven Frucht,Horacio Kaufmann,Victor W. Nitti,Benjamin M. 대한배뇨장애요실금학회 2019 International Neurourology Journal Vol.23 No.3
Purpose: To assess the urodynamic findings in patients with Parkinson disease (PD) with overactive bladder symptoms. Methods: We performed a retrospective chart review of all PD patients who were seen in an outpatient clinic for lower urinary tract symptoms (LUTS) between 2010 and 2017 in a single-institution. Only patients who complained of overactive bladder (OAB) symptoms and underwent a video-urodynamic study for these symptoms were included. We excluded patients with neurological disorders other than PD and patients with voiding LUTS but without OAB symptoms. Results: We included 42 patients (29 men, 13 women, 74.5±8.1 years old). Seven patients (16.7%) had a postvoid residual (PVR) bladder volume >100 mL and only one reported incomplete bladder emptying. Detrusor overactivity (DO) was found in all 42 patients (100%) and was terminal in 19 (45.2%) and phasic in 22 patients (52.4%). Eighteen patients had detrusor underactivity (DU) (42.3%). Later age of PD diagnosis was the only parameter associated with DU (P=0.02). Patients with bladder outlet obstruction (BOO) were younger than patients without BOO (70.1 years vs. 76.5 years, P=0.004), had later first sensation of bladder filling (173.5 mL vs. 120.3 mL, P=0.02) and first involuntary detrusor contraction (226.4 mL vs. 130.4 mL, P=0.009). Conclusions: DO is almost universal in all patients with PD complaining of OAB symptoms (97.1%). However, a significant percentage of patients also had BOO (36.8%), DU (47%), and increased PVR (16.7%) indicating that neurogenic DO may not be the only cause of OAB symptoms in PD patients.
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Cho, Eun-Jin,Yang, Jaemoon,Mohamedali, Khalid A.,Lim, Eun-Kyung,Kim, Eun-Jung,Farhangfar, Carol J.,Suh, Jin-Suck,Haam, Seungjoo,Rosenblum, Michael G.,Huh, Yong-Min Lippincott Williams Wilkins, Inc. 2011 Vol. No.
OBJECTIVES:: To investigate the efficiency of magnetic resonance imaging (MRI) contrast agents employing vascular endothelial growth factor (VEGF121)/rGel conjugated MnFe2O4 nanocrystals for imaging of neovasculature using a bladder tumor model. MATERIALS AND METHODS:: VEGF121/rGel was conjugated to MnFe2O4 nanoparticles (MNPs). The targeting efficiency and detection capability of the VEGF121/rGel-MNPs were investigated in both KDR-deficient (253JB-V) and KDR-overexpressing (PAE/KDR) cells using MRI. The internalization of VEGF121/rGel-MNPs into cells was confirmed by electron microscopy. Their phosphorylation ability and cytotoxicity were compared with unconjugated VEGF121/rGel. The orthotopic tumor mice were established by implanting low KDR-expressing 253JB-V cells into the bladder dome. After tail-vein injection of VEGF121/rGel-MNPs, the MR signal enhancement of intratumoral vessels by VEGF121/rGel-MNPs was observed and inhibition test using VEGF121 was also conducted. Ex vivo MR imaging of tumor tissue, and a fluorescence immunostaining study was also performed. RESULTS:: The water-soluble VEGF121/rGel-MNPs (44.5 ± 1.2 nm) were stably suspended in the biologic media and exhibited a high relaxivity coefficient (423 mMs). They demonstrated sufficient targeting capability against KDR-overexpressing PAE/KDR cells, as confirmed by dose-dependent MR images and VEGF121 inhibition tests. The phosphorylation activity of KDR and cytotoxicity of VEGF121/rGel-MNPs were evaluated. VEGF121/rGel-MNPs successfully targeted the tumor and provided accurate anatomic details through (i) acquisition of clear neoangiogenic vascular distributions and (ii) obvious enhancement of the MR signal in T2*-weighted images. Immunostaining and blocking studies demonstrated the specific targeting ability of VEGF121/rGel-MNPs toward intratumoral angiogenesis. CONCLUSIONS:: Synthesized VEGF121/rGel-MNPs as targeted MR imaging contrast agents can be specifically delivered to tumors and bind to KDR-expressing angiogenic tumor vessels.
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