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Park, Min Soo,Rieger-Fackeldey, Esther,Schanbacher, Brandon L,Cook, Angela C,Bauer, John A,Rogers, Lynette K,Hansen, Thomas N,Welty, Stephen E,Smith, Charles V Williams & Wilkins Co.[etc.] 2007 Pediatric research Vol.62 No.6
<P>In the present study, we tested the hypothesis that exposure of newborn mice to sublethal hyperoxia would alter lung development and expressions of fibroblast growth factor receptors (FGFRs)-3 and FGFR-4. Newborn FVB mice were exposed to 85% O2 or maintained in room air for up to 14 d. No animal mortality was observed, and body weight gains were not affected by hyperoxia. At postnatal d 7 and 14 (P7, P14), lungs of mice exposed to 85% O2 showed fewer alveolar secondary crests and larger alveoli or terminal air spaces than did mice in room air. In pups kept in room air, lung levels of FGFR-3 and FGFR-4 mRNA were greater at P3 than at P1, but similar increases were not observed in hyperoxic mice. Immunoreactivity of FGFR-3 and FGFR-4 was lower in lungs of hyperoxic mice than in controls at P14. In pups kept in room air, lung fibroblast growth factor (FGF)-7 mRNA levels were greater at P14 than at P1, but similar changes were not observed in hyperoxic mice. The temporally and spatially specific alterations in the expressions of FGFR-3, FGFR-4, and FGF-7 in the mice exposed to hyperoxia may contribute to aberrant lung development.</P>
Lee, Deok-Sun,Sadjadi, Zeinab,Rieger, Heiko Published by the American Physical Society through 2014 Physical review. E, Statistical, nonlinear, and so Vol.90 No.1
<P>Recently, anomalous scaling properties of front broadening during spontaneous imbibition of water in Vycor glass, a nanoporous medium, were reported: the mean height and the width of the propagating front increase with time t both proportional to t(1/2). Here, we propose a simple lattice imbibition model and elucidate quantitatively how the correlation range of the hydrostatic pressure and the disorder strength of the pore radii affect the scaling properties of the imbibition front. We introduce an effective tension of liquid across neighboring pores, which depends on the aspect ratio of each pore, and show that it leads to a dynamical crossover: both the mean height and the roughness grow faster in the presence of tension in the intermediate-time regime but eventually saturate in the long-time regime. The universality class of the long-time behavior is discussed by examining the associated scaling exponents and their relation to directed percolation.</P>
Tunnel Effect in CNNs: Image Reconstruction From Max Switch Locations
de La Roche Saint Andre, Matthieu,Rieger, Laura,Hannemose, Morten,Kim, Junmo IEEE Signal Processing Society 2017 IEEE signal processing letters Vol.24 No.3
<P>In this letter, we show that reconstruction of an image passed through a neural network is possible, using only the locations of the max pool activations. This was demonstrated with an architecture consisting of an encoder and a decoder. The decoder is amirrored version of the encoder, where convolutions are replaced with deconvolutions and poolings are replaced with unpooling layers. The locations of the max pool switches are transmitted to the corresponding unpooling layer. The reconstruction is computed only from these switches without the use of feature values. Using only the max switch location information of the pool layers, a surprisingly good image reconstruction can be achieved. We examine this effect in various architectures, as well as how the quality of the reconstruction is affected by the number of features. We also compare the reconstruction with an encoder with randomly initialized weights with an encoder pretrained for classification. Finally, we give recommendations for future architecture decisions.</P>
Thies BEINKE,Moritz QUANDT,Abderrahim AIT ALLA,Michael FREITAG,Thomas RIEGER 국제이네비해양경제학회 2017 International Journal of e-Navigation and Maritime Vol.8 No.1
For the German energy transition, offshore wind energy is a significant factor of success. The number of installed offshore wind energy turbines is steadily increasing. Currently, the subject matter of offshore wind energy turbine maintenance and its optimization is increasingly in the focus of research and development work. The present contribution examines the logistics of offshore wind energy turbine maintenance and the impact of the actual sea state and of sea state forecasts. To this end, the coordination processes between the players involved in the planning of service operations will be presented and analysed. Based on this, the impact of the quality of wave height forecasts on operation decisions and the mean time to repair will be determined as well as the availability of the turbines at different forecast quality levels. Proceeding on the basis of these results, the concept of a decision-making support system for operative logistics planning will be presented.
Safety of long-term subcutaneous free flap skin banking after skin-sparing mastectomy
Verstappen, Ralph,Djedovic, Gabriel,Morandi, Evi Maria,Heiser, Dietmar,Rieger, Ulrich Michael,Bauer, Thomas Korean Society of Plastic and Reconstructive Surge 2018 Archives of Plastic Surgery Vol.45 No.2
Background A persistent problem in autologous breast reconstruction in skin-sparing mastectomies is skin restoration after skin necrosis or secondary oncological resection. As a solution to facilitate reconstruction, skin banking of free-flap skin has been proposed in cases where the overlying skin envelope must be resected, as this technique spares the patient an additional donor site. Herein, we present the largest series to date in which this method was used. We investigated its safety and the possibility of skin banking for prolonged periods of time. Methods All skin-sparing mastectomies and immediate autologous breast reconstructions from December 2009 until June 2013 at our institution were analysed. Results We identified 31 patients who underwent 33 free flap reconstructions in which skin banking was performed. Our median skin banking period was 7 days, with a maximum duration of 171 days. In 22.5% of cases, the banked skin was used to reconstruct overlying skin defects, and in 9.6% of cases to reconstruct the nipple-areolar complex. Microbiological and histological investigations of the banked skin revealed neither clinical infections nor malignancies. Conclusions In situ skin banking, even for prolonged periods of time, is a safe and cost-effective method to ensure that skin defects due to necrosis or secondary oncological resection can be easily reconstructed.
Safety of long-term subcutaneous free flap skin banking after skin-sparing mastectomy
Ralph Verstappen,Gabriel Djedovic,Evi Maria Morandi,Dietmar Heiser,Ulrich Michael Rieger,Thomas Bauer 대한성형외과학회 2018 Archives of Plastic Surgery Vol.45 No.2
Background A persistent problem in autologous breast reconstruction in skin-sparing mastectomies is skin restoration after skin necrosis or secondary oncological resection. As a solution to facilitate reconstruction, skin banking of free-flap skin has been proposed in cases where the overlying skin envelope must be resected, as this technique spares the patient an additional donor site. Herein, we present the largest series to date in which this method was used. We investigated its safety and the possibility of skin banking for prolonged periods of time. Methods All skin-sparing mastectomies and immediate autologous breast reconstructions from December 2009 until June 2013 at our institution were analysed. Results We identified 31 patients who underwent 33 free flap reconstructions in which skin banking was performed. Our median skin banking period was 7 days, with a maximum duration of 171 days. In 22.5% of cases, the banked skin was used to reconstruct overlying skin defects, and in 9.6% of cases to reconstruct the nipple-areolar complex. Microbiological and histological investigations of the banked skin revealed neither clinical infections nor malignancies. Conclusions In situ skin banking, even for prolonged periods of time, is a safe and cost-effective method to ensure that skin defects due to necrosis or secondary oncological resection can be easily reconstructed.
Abdulwares Meiwandi,Lars Kamper,Lara Küenzlen,Ulrich M. Rieger,Ahmet Bozkurt 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.5
Background Reconstruction of large soft tissue defects of the lower extremity often requires the use of free flaps. The main limiting factor and potential for complications lie in the selection of proper donor and recipient vessels formicrovascular anastomosis. While the superficial veins of the lower leg are easier to dissect, they are thought to be more vulnerable to trauma and lead to a higher complication rate when using them instead of the deep accompanying veins as recipient vessels. No clear evidence exists that proves this concept. Methods We retrospectively studied the outcomes of 97 patients who underwent free flap plasty to reconstruct predominantly traumatic defects of the lower extremity at our institute. The most used flap was the gracilis muscle flap. We divided the population into three groups based on the recipient veins that were used for microvascular anastomosis and compared their outcomes. The primary outcome was the major complication rate. Results Overall flap survivability was 93.81%. The complication rates were not higher when using the great saphenous vein as a recipient vessel when comparing to utilizing the deep concomitant veins alone or the great saphenous vein in combination to the concomitant veins. Conclusions In free flap surgery of the lower extremity, the selection of the recipient veins should not be restricted to the deep accompanying veins of themain vessels. The superficial veins, especially the great saphenous vein, offer an underrated option when performing free flap reconstruction.
Mastectomy in female-to-male transgender patients: A single-center 24-year retrospective analysis
Kuhn, Shafreena,Keval, Seirah,Sader, Robert,Kuenzlen, Lara,Kiehlmann, Marcus,Djedovic, Gabriel,Bozkurt, Ahmet,Rieger, Ulrich Michael Korean Society of Plastic and Reconstructive Surge 2019 Archives of Plastic Surgery Vol.46 No.5
Background Mastectomy in male transgender patients is an important (and often the first) step toward physical manhood. At our department, mastectomies in transgender patients have been performed for several decades. Methods Recorded data were collected and analyzed for all male transgender patients undergoing mastectomy over a period of 24 years at our department. Results In total, 268 gender-reassigning mastectomies were performed. Several different mastectomy techniques (areolar incision, n=172; sub-mammary incision, n=96) were used according to patients' habitus and breast features. Corresponding to algorithms presented in the current literature, certain breast qualities were matched with a particular mastectomy technique. Overall, small breasts with marginal ptosis and good skin elasticity allowed small areolar incisions as a method of access for glandular removal. In contrast, large breasts and those with heavy ptosis or poor skin elasticity often required larger incisions for breast amputation. The secondary correction rate (38%) was high for gender reassignment mastectomy, as is also reflected by data in the current literature. Secondary correction frequently involved revision of chest wall recontouring, suggesting inadequate removal of the mammary tissue, as well as scar revision, which may reflect intense traction during wound healing (36%). Secondary corrections were performed more often after using small areolar incision techniques (48%) than after using large sub-mammary incisions (21%). Conclusions Choosing the suitable mastectomy technique for each patient requires careful individual evaluation of breast features such as size, degree of ptosis, and skin elasticity in order to maximize patient satisfaction and minimize secondary revisions.