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Hong, Myeongjin,Ryu, Leesun,Ow, Maria C.,Kim, Jinmahn,Je, A Reum,Chinta, Satya,Huh, Yang Hoon,Lee, Kea Joo,Butcher, Rebecca A.,Choi, Hongsoo,Sengupta, Piali,Hall, Sarah E.,Kim, Kyuhyung Current Biology Ltd 2017 Current Biology Vol.27 No.20
<P><B>Summary</B></P> <P>Experiences during early development can influence neuronal functions and modulate adult behaviors []. However, the molecular mechanisms underlying the long-term behavioral effects of these early experiences are not fully understood. The <I>C. elegans</I> ascr#3 (asc-ΔC9; C9) pheromone triggers avoidance behavior in adult hermaphrodites []. Here, we show that hermaphrodites that are briefly exposed to ascr#3 immediately after birth exhibit increased ascr#3-specific avoidance as adults, indicating that ascr#3-experienced animals form a long-lasting memory or imprint of this early ascr#3 exposure []. ascr#3 imprinting is mediated by increased synaptic activity between the ascr#3-sensing ADL neurons and their post-synaptic SMB motor neuron partners via increased expression of the <I>odr-2</I> glycosylated phosphatidylinositol (GPI)-linked signaling gene in the SMB neurons. Our study suggests that the memory for early ascr#3 experience is imprinted via alteration of activity of a single synaptic connection, which in turn shapes experience-dependent plasticity in adult ascr#3 responses.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Early pheromone exposure modulates behavioral responses to the pheromone as adults </LI> <LI> Pheromone experience is imprinted as increased synaptic activity </LI> <LI> The <I>odr-2</I> GPI-linked signaling protein mediates pheromone imprinting </LI> </UL> </P>
Park, Jisoo,Choi, Woochan,Dar, Abdul Rouf,Butcher, Rebecca A.,Kim, Kyuhyung Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.1
Animals need to be able to alter their developmental and behavioral programs in response to changing environmental conditions. This developmental and behavioral plasticity is mainly mediated by changes in gene expression. The knowledge of the mechanisms by which environmental signals are transduced and integrated to modulate changes in sensory gene expression is limited. Exposure to ascaroside pheromone has been reported to alter the expression of a subset of putative G protein-coupled chemosensory receptor genes in the ASI chemosensory neurons of C. elegans (Kim et al., 2009; Nolan et al., 2002; Peckol et al., 1999). Here we show that ascaroside pheromone reversibly represses expression of the str-3 chemoreceptor gene in the ASI neurons. Repression of str-3 expression can be initiated only at the L1 stage, but expression is restored upon removal of ascarosides at any developmental stage. Pheromone receptors including SRBC-64/66 and SRG-36/37 are required for str-3 repression. Moreover, pheromone-mediated str-3 repression is mediated by FLP-18 neuropeptide signaling via the NPR-1 neuropeptide receptor. These results suggest that environmental signals regulate chemosensory gene expression together with internal neuropeptide signals which, in turn, modulate behavior.
박지수,최우찬,Abdul Rouf Dar,Rebecca A. Butcher,김규형 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.1
Animals need to be able to alter their developmental and behavioral programs in response to changing environmental conditions. This developmental and behavioral plasticity is mainly mediated by changes in gene expression. The knowledge of the mechanisms by which environmental signals are transduced and integrated to modulate changes in sensory gene expression is limited. Exposure to ascaroside pheromone has been reported to alter the expression of a subset of putative G protein-coupled chemosensory receptor genes in the ASI chemosensory neurons of C. elegans (Kim et al., 2009; Nolan et al., 2002; Peckol et al., 1999). Here we show that ascaroside pheromone reversibly represses expression of the str-3 chemoreceptor gene in the ASI neurons. Repression of str-3 expression can be initiated only at the L1 stage, but expression is restored upon removal of ascarosides at any developmental stage. Pheromone receptors including SRBC-64/66 and SRG-36/37 are required for str-3 repression. Moreover, pheromone-mediated str-3 repression is mediated by FLP-18 neuropeptide signaling via the NPR-1 neuropeptide receptor. These results suggest that environmental signals regulate chemosensory gene expression together with internal neuropeptide signals which, in turn, modulate behavior.
Jang, H.,Kim, K.,Neal, Scott J.,Macosko, E.,Kim, D.,Butcher, Rebecca A.,Zeiger, Danna M.,Bargmann, Cornelia I.,Sengupta, P. Cell Press 2012 Neuron Vol.75 No.4
Pheromone responses are highly context dependent. For example, the C. elegans pheromone ascaroside C9 (ascr#3) is repulsive to wild-type hermaphrodites, attractive to wild-type males, and usually neutral to ''social'' hermaphrodites with reduced activity of the npr-1 neuropeptide receptor gene. We show here that these distinct behavioral responses arise from overlapping push-pull circuits driven by two classes of pheromone-sensing neurons. The ADL sensory neurons detect C9 and, in wild-type hermaphrodites, drive C9 repulsion through their chemical synapses. In npr-1 mutant hermaphrodites, C9 repulsion is reduced by the recruitment of a gap junction circuit that antagonizes ADL chemical synapses. In males, ADL sensory responses are diminished; in addition, a second pheromone-sensing neuron, ASK, antagonizes C9 repulsion. The additive effects of these antagonistic circuit elements generate attractive, repulsive, or neutral pheromone responses. Neuronal modulation by circuit state and sex, and flexibility in synaptic output pathways, may permit small circuits to maximize their adaptive behavioral outputs.