http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Systematic Analysis on the GSTM1 Null Phenotype and Prostate Cancer Risk in Chinese People
Shi, Jing,Zhuang, Yan,Liu, Yan,Yan, Cheng-Quan,Liu, Xian-Kui,Zhang, Ying Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Objective: Glutathione S-transferase M 1 (GSTM1) is implicated as a risk factor for prostate cancer. However, this issue is not clear in Chinese population. This systemic analysis was conducted to evaluate the effect of GSTM1 null genotypes on prostate cancer risk in Chinese. Methods: Published studies investigating the associations between GSTM1 null genotypes and the risk of prostate cancer in China were identified by using a predefined search strategy. Main statisticals were pooled and estimated according to the primarily reported data. Results: The prevalence of the GSTM1 null genotype was higher in prostate cancer patients than in controls, with significance. Conclusion: The GSTM1 null genotypes is associated with increased risk of prostate cancer in Chinese.
Quan, Yan-Shi,Naruse, Kenji,Kim, Baek-Chul,Kim, Hong-Rye,Han, Rang-Xun,Choi, Su-Min,Park, Chang-Sik,Jin, Dong-Il The Korean Society of Animal Reproduction 2007 Reproductive & developmental biology Vol.31 No.4
Insulin, transferrin and selenium (ITS) complex is reported to improve in vitro development of oocytes and embryos. This study was carried out to investigate the effects of ITS during in vitro culture (IVC) of porcine parthenogenetic and nuclear transfer (NT) embryos on subsequent developmental capacity in vitro. The electrically activated oocytes were cultured in Porcine Zygote Medium (PZM-3) with various concentrations (0, 0.1, 0.5, and 1.0%) of ITS for 7 days. Also, the electrically activated reconstructed embryos were cultured in PZM-3 with various concentrations (0, 0.1, 0.5, and 1.0%) of ITS for 6 days. Addition of ITS to culture medium did not affect development of porcine parthenogenetic embryos in vitro. To test the effect of ITS on the in vitro development of porcine NT embryos, factorial experiments were also performed for in vitro maturation (IVM) medium (TCM-199) with or without 1% ITS and culture medium (PZM-3) with or without 0.5% ITS. Addition of 0.5% ITS to culture medium increased (p<0.05) the proportion of NT blastocysts compared with non-treated group. In contrast, addition of 1% ITS to culture medium was ineffective or had a detrimental effect. Also, addition of ITS only to maturation medium increased (p<0.05) the percentage of NT blastocysts formation compared with the control group. In conclusion, addition of ITS to IVM or IVC medium could improve subsequent blastocyst development of porcine NT embryos.
Yan Shi Quan,Kenji Naruse,Baek Chul Kim,Hong Rye Kim,Rong Xun Han,Su Min Choi,Chang Sik Park,Dong Il Jin 한국동물생명공학회(구 한국동물번식학회) 2007 Reproductive & developmental biology Vol.31 No.4
Insulin, transferrin and selenium (ITS) complex is reported to improve in vitro development of oocytes and embryos. This study was carried out to investigate the effects of ITS during in vitro culture (IVC) of porcine parthenogenetic and nuclear transfer (NT) embryos on subsequent developmental capacity in vitro. The electrically activated oocytes were cultured in Porcine Zygote Medium (PZM-3) with various concentrations (0, 0.1, 0.5, and 1.0%) of ITS for 7 days. Also, the electrically activated reconstructed embryos were cultured in PZM-3 with various concentrations (0, 0.1, 0.5, and 1.0%) of ITS for 6 days. Addition of ITS to culture medium did not affect development of porcine parthenogenetic embryos in vitro. To test the effect of ITS on the in vitro development of porcine NT embryos, factorial experiments were also performed for in vitro maturation (IVM) medium (TCM-199) with or without 1% ITS and culture medium (PZM-3) with or without 0.5% ITS. Addition of 0.5% ITS to culture medium increased (p<0.05) the proportion of NT blastocysts compared with non-treated group. In contrast, addition of 1% ITS to culture medium was ineffective or had a detrimental effect. Also, addition of ITS only to maturation medium increased (p<0.05) the percentage of NT blastocysts formation compared with the control group. In conclusion, addition of ITS to IVM or IVC medium could improve subsequent blastocyst development of porcine NT embryos.
Yan Shi Quan,Kenji Naruse,Su Min Choi,Myung Youn Kim,Rong Xun Han,Chang Sik Park,Dong Il Jin 한국동물생명공학회(구 한국동물번식학회) 2008 Reproductive & developmental biology Vol.32 No.4
Interspecies somatic cell nuclear transfer (iSCNT) is a valuable tool for studying the interactions between an oocyte and somatic nucleus. The object of this study was to investigate the developmental competence of in vitro‐matured porcine oocytes after transfer of the somatic cell nuclei of 2 different species (goat and rabbit). Porcine cumulus oocytes were obtained from the follicles of ovaries and matured in TCM‐199. The reconstructed embryos were electrically fused with 2 DC pulses of 1.1 kV/cm for 30 μs in 0.3 M mannitol medium. The activated cloned embryos were cultured in porcine zygote medium‐3 (PZM‐3), mSOF or RDH medium for 7 days. The blastocyst formation rate of the embryos reconstructed from goat or rabbit fetal fibroblasts was significantly lower than that of the embryos reconstructed from porcine fetal fibroblast cells. However, a significantly higher number of embryos reconstructed from goat or rabbit fetal fibroblasts cultured in mSOF or RDH, respectively, developed to the morular stage than those cultured in PZM‐3. These results suggest that goat and bovine fetal fibroblasts were less efficacious than porcine‐porcine cloned embryos and that culture condition could be an important factor in iSCNT. The lower developmental potential of goat‐porcine and porcine‐bovine cloned embryos may be due to incompatibility between the porcine oocyte cytoplasm and goat and bovine somatic nuclei.
Quan, Yan Shi,Naruse, Kenji,Choi, Su-Min,Kim, Myung-Youn,Han, Rong-Xun,Park, Chang-Sik,Jin, Dong-Il The Korean Society of Animal Reproduction 2008 Reproductive & developmental biology Vol.32 No.4
Interspecies somatic cell nuclear transfer (iSCNT) is a valuable tool for studying the interactions between an oocyte and somatic nucleus. The object of this study was to investigate the developmental competence of in vitro-matured porcine oocytes after transfer of the somatic cell nuclei of 2 different species (goat and rabbit). Porcine cumulus oocytes were obtained from the follicles of ovaries and matured in TCM-199. The reconstructed embryos were electrically fused with 2 DC pulses of 1.1kV/cm for $30{\mu}s$ 0.3M mannitol medium. The activated cloned embryos were cultured in porcine zygote medium-3 (PZM-3), mSOF or RDH medium for 7 days. The blastocyst formation rate of the embryos reconstructed from goat or rabbit fetal fibroblasts was significantly lower than that of the embryos reconstructed from porcine fetal fibroblast cells. However, a significantly higher number of embryos reconstructed from goat or rabbit fetal fibroblasts cultured in mSOF or RDH, respectively, developed to the morular stage than those cultured in PZM-3. These results suggest that goat and bovine fetal fibroblasts were less efficacious than porcine-porcine cloned embryos and that culture condition could be an important factor in iSCNT. The lower developmental potential of goat-porcine and porcine-bovine cloned embryos may be due to incompatibility between the porcine oocyte cytoplasm and goat and bovine somatic nuclei.
Shi-Ben Wang,Xian-Qing Deng,Yan Zheng,Hong-Jian Zhang,Zhe-Shan Quan 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.1
Two series of 8-alkoxy-5-(4H-1,2,4-triazol-4-yl)quinolines and 8-alkoxy-5-(2H-1,2,4-triazol-3-one-4-yl)quinolineswere synthesized.The anticonvulsant activity ofthese compounds was evaluated with maximal electroshockseizure test and rotarod test. Among the synthesized compounds,8-octoxy-5-(4H-1,2,4-triazol-4-yl)quinoline (4g)was the most active compound with ED50 of 8.80 mg/kg,TD50 of 176.03 mg/kg and protective index of 20.0. Itsneurotoxicity was lower than all other synthesized compoundsand also markedly lower than that of the referencedrug carbamazepine. In addition, the potency of compound 4gagainst seizures induced by pentylenetetrazole, 3-mercaptopropionicacid, and bicuculline suggested its broad spectrumactivity, and the mechanisms of action including inhibition ofvoltage-gated ion channels and modulation of GABAergicactivity might involve in its anticonvulsant activity.
Zhi-Quan Cui,Shi-Sheng Zhong,Zhi-Qi Yan 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.6
In order to solve the problem of neural network algorithm for aero-engine’s gas path performance evaluation under high-dimensional evaluation index with non-equal weights, the trend analysis method and fault fingerprints are used to mine engine’s gas path performance characteristic parameters. A comprehensive weighting method based on game theory is proposed to optimize the weight value of each gas path performance characteristic parameter. A discrete feedback neural network with single-layer and binary output is established. The original gas path performance evaluation index is equivalently expanded according to the weight ratio, and the gas path state evaluation indexes with different weights are mapped into higher-dimensional equivalent evaluation indexes with equal weights. The network attractor is designed according to the engine gas path performance evaluation levels, and the design of discrete feedback neural network weights is transformed into multi-objective programming problem, and a particle swarm optimization algorithm with adaptive inertia weight is used to improve the efficiency and global search ability of particle swarm optimization. The experimental results shows that the proposed model and algorithm can provide a scientific and reasonable machine learning method for the evaluation of high-dimensional evaluation index with non-equal weights.