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Rukmini Mridula Kandadai,Praveen Yada,Megha S. Uppin,Shaik Afshan Jabeen,Ajith Cherian,Meena Angamuthu Kanikannan,Rupam Borgohain,Sundaram Challa 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.4
Background Subacute sclerosing panencephalitis (SSPE) is a delayed and fatal manifestationof measles infection. Fulminant SSPE is a rare presentation in which the disease progresses todeath over a period of 6 months. The clinical features are atypical and can be misleading. Case Report We report herein a teenage boy who presented with acute-onset gait ataxia followed by right hemiparesis that evolved over 1 month, with left-hemispheric, delta-range slowing on the electroencephalogram (EEG). Magnetic resonance imaging disclosed multiple whitematter hyperintensities, suggesting a diagnosis of acute disseminated encephalomyelitis. Hereceived intravenous steroids, and within 4 days of hospital admission he developed unilateralslow myoclonic jerks. Repeat EEG revealed Rademecker complexes, pathognomonic of SSPE,and an elevated titer of IgG antimeasles antibodies was detected in his cerebrospinal fluid. Thedisease progressed rapidly and the patient succumbed within 15 days of hospitalization. The diagnosis of SSPE was confirmed by autopsy. Conclusions This case illustrates the difficulty of recognizing fulminant SSPE when it manifests with asymmetric clinical and EEG abnormalities.