http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Examining DeLone and McLean Model for Online Public Grievance Redressal System of Nepal
KC Pramod,Deuk J. Bae 국제문화기술진흥원 2019 International Journal of Advanced Culture Technolo Vol.7 No.1
This paper is to explore the success factors of the online public grievance redressal system in the Nepal. It empirically tests the conceptual path model developed by DeLone and McLean which consists of six social perception variables with regard to citizen's intention to use the system. The estimates from 577 respondents support all the 13 hypotheses generated from D&L model. People's attitude and social norms are the two most important factors on the continuous usage of the system. It is suggested that the social factors are as much important as technological aspects when it comes to the e-government implementation. It is also suggested that the government should pay more attention to human factors in upgrading the design and development of e-grievance system in the foreseeable future.
Examining DeLone and McLean Model for Online Public Grievance Redressal System of Nepal
Pramod, KC,Bae, Deuk J. The International Promotion Agency of Culture Tech 2019 International Journal of Advanced Culture Technolo Vol.7 No.1
This paper is to explore the success factors of the online public grievance redressal system in the Nepal. It empirically tests the conceptual path model developed by DeLone and McLean which consists of six social perception variables with regard to citizen's intention to use the system. The estimates from 577 respondents support all the 13 hypotheses generated from D&L model. People's attitude and social norms are the two most important factors on the continuous usage of the system. It is suggested that the social factors are as much important as technological aspects when it comes to the e-government implementation. It is also suggested that the government should pay more attention to human factors in upgrading the design and development of e-grievance system in the foreseeable future.
Yong Heo,JiHun Jo,Ravi Gautam,Manju Acharya,Pramod KC,Anju Maharjan,DaEun Lee,ChangYul Kim,HyoungAh Kim,GyoungWoo Lee,HyeJin Kang,JunHo Sin,YeongEun Yu,SeungYi Seo 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Microplastics (MPs) have been recently recognized as a global environmental threat and its exposure as a risk factor to human health. Health effects through MPs exposure have been recently reported, whereas not much evaluation on immunotoxicity of MP has been reported. The present study was designed to evaluate whether polyethylene MPs (PE-MPs) subacute exposure through intragastric intubation could be immunotoxic to ICR mice. PEs with 5 or 50 μm diameter were administered to 6 wk old female and male mice at 0 (distilled water, vehicle control), 500 (low), and 1000 (middle), or 2000 (high) mg/day for 4 wks. No influence of the exposure on thymic T lymphocyte development was observed due to no difference in thymic lymphocyte subpopulation through flow cytometer analysis among the groups. Proportions of splenic CD4(+) and B lymphocyte were higher without statistical significances in the exposure groups than the vehicle control regardless of dose and gender. Serum IgG2a:IgG1 ratio was dose-dependently elevated in the male and female 5 μm PE exposure group, which pattern was not observed with 50 μm exposure group. Furthermore, ratios of IFN-gamma:IL-4, a parameter for predicting balance between type-1 and type-2 immune reactivity in helper T lymphocytes stimulated ex vivo with phytohemagglutinin for 48h, were higher in the male 5 μm PE exposure group than the control, but not observed in the female 5 μm and the 50 μm exposure group of both genders. Overall, the present study indicates that exposure to PE-MPs could alter immune homeostasis, especially to smaller size of MPs. Investigation on size-dependent and plastic type-related immune modulation should be advanced. [supported by the Korea Environmental Industry & Technology Institute (No.2020003120002) and the Ministry of Environment-Educational training program for the management of information on the hazards and risk of chemical substances]
Maharjan, Anju,Gautam, Ravi,Jo, JiHun,Acharya, Manju,Lee, DaEun,Pramod, Bahadur KC,Gim, Jin,Sin, Sojung,Kim, Hyocher,Kim, ChangYul,Lee, SooYeon,Lee, SooJin,Heo, Yong,Kim, HyoungAh Occupational Safety and Health Research Institute 2022 Safety and health at work Vol.13 No.2
Background: Occupational hazards in crop farms vary diversely based on different field operations as soil management, harvesting processes, pesticide, or fertilizer application. We aimed at evaluating the immunological status of crop farmers, as limited systematic investigations on immune alteration involved with crop farming have been reported yet. Methods: Immunological parameters including plasma immunoglobulin level, major peripheral immune cells distribution, and level of cytokine production from activated T cell were conducted. Nineteen grape orchard, 48 onion open-field, and 21 rose greenhouse farmers were participated. Results: Significantly low proportion of natural killer (NK) cell, a core cell for innate immunity, was revealed in the grape farmers (19.8±3.3%) in comparison to the onion farmers (26.4±3.1%) and the rose farmers (26.9±2.5%), whereas cytotoxic T lymphocyte proportion was lower in the grape and the onion farmers than the rose farmers. The proportion of NKT cell, an immune cell implicated with allergic response, was significantly higher in the grape (2.3±0.3%) and the onion (1.6±0.8%) farmers compared with the rose farmers (1.0±0.4%). A significantly decreased interferon-gamma:interleukin-13 ratio was observed from ex vivo stimulated peripheral blood mononuclear cells of grape farmers compared with the other two groups. The grape farmers revealed the lowest levels of plasma IgG1 and IgG4, and their plasma IgE level was not significantly different from that of the onion or the rose farmers. Conclusion: Our finding suggests the high vulnerability of workplace-mediated allergic immunity in grape orchard farmers followed by open-field onion farmers and then the rose greenhouse farmers.
Ravi Gautam,DaEun Lee,Anju Maharjan,Manju Acharya,JiHun Jo,HyunJi Park,YuBin Kim,Pramod Bahadur KC,Chang Yul Kim,HyoungAh Kim,JiMin Choi,SooMin Lim,YoungWoo Shin,SuBin Yang,Yong Heo 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Nanoparticles (NPs), fine particles ranging from 1 to 100 nm, are being used extensively in various fields including industry, agriculture, engineering. Nanoparticles also have become the imperative parts of cosmetic and dermal products owing to the higher benefits over their counter bulk particles. Manganese oxide (Mn2O3) and copper oxide (CuO) are used in cosmetics and dermal products owing to their UV protection and antimicrobial properties and also to make products transparent and aesthetically acceptable. Although Mn2O3 and CuO are used in consumer products that get exposed to the skin, their skin sensitization potential has not been well investigated. In this study we employed, Local lymph node assay: 5-bromo-2-deoxyuridine-flow cytometry method (LLNA: BrdU-FCM) to predict the skin sensitization (SS) potential of nanoparticles. LLNA: BrdU-FCM is a method for screening of SS potential that addressed the activation and proliferation of T-lymphocytes, key event-4 (KE-4), on adverse outcome pathway (AOP) for SS. Mn2O3 (5%, 10%, and 25%), and CuO (5%, 10%, and 25 %) NPs were suspended in dimethyl sulfoxide (DMSO) for experimentation. AOO (acetone: olive oil = 4:1) and α-hexyl cinnamaldehyde were used as negative and positive control respectively. Mn2O3 and CuO NPs were both classified as non-sensitizer with maximum stimulation indices of 1.4 and 0.99 respectively. Although both NPs were classified as non-sensitizer using LLNA: BrdU-FCM, further assays addressing other KEs of AOP for SS could be carried out as confirmation and cautious use of products containing these nanoparticles is recommended as various studies have revealed their toxicity in vitro . This study was supported by the Korea National Research Foundation (grant number: 2020R1I1A3A0403650911) and the Ministry of Environment-Educational training program for the management of information on the hazards and risk of chemical substances.
Ravi Gautam,Ji Hun Jo,Ha Jung Han,Anju Maharjan,Manju Acharya,Da Eun Lee,Hyun Ji Park,Yu Bin Kim,Ji Sun Lee,Jin Ho Kim,Pramod Bahadur KC,Chang Yul Kim,Yong Heo 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Exposure to metal arsenic (As) has been proposed as a risk factor for autism spectrum disorders (ASDs), which are neurodevelopmental disorders with worldwide increasing in its incidence. In the present study, BTBR T+tf/J (BTBR) mice with ASD-like behavioral characteristics and control highly social FVB mice were orally exposed to 0.1 mM arsenic (III) oxide for 4 wk, and were compared to investigate neuroimmunological or behavioral abnormalities. IgG1:IgG2a ratios in brain tissues from BTBR mice exposed to As (BTBR-As) were significantly higher than those of BTBR-control mice (BTBR-C), but this change did not occur in FVB mice exposed to As. Levels of IL-4, IFN-γ, IL-1β, IL-17, and TNF-α in brain tissue were lowered in BTBR-As relative to BTBR-C, but this tendency was not observed with FVB mice. BTBR-As mice demonstrated decrease in relative travel distance and time spent in the center vs. the periphery of open field arena compared to BTBR-C. Sociability evaluation using three-way chamber test did not clearly demonstrate As-mediated alteration in social interaction in BTBR mice. These findings suggest the potential for As-driven predominant T H2-like reactivity profile in the brain microenvironment of BTBR mice and for As-mediated locomotive impairment probably associated with ASD. This study was supported by research grant from Daegu Catholic University in 2019 and the Ministry of Environment-Educational training program for the management of information on the hazards and risk of chemical substances.