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Over-expression of thymosin beta4 promotes abnormal tooth development and stimulation of hair growth
Cha, Hee-Jae,Philp, Deborah,Lee, Soo-Hyun,Moon, Hye-Sung,Kleinman, Hynda K.,Nakamura, Takashi UPV/EHU Press 2010 The International journal of developmental biology Vol.54 No.1
<P>Thymosin beta 4 has multi-functional roles in cell physiology. It accelerates wound healing, hair growth and angiogenesis, and increases laminin-5 expression in corneal epithelium. Furthermore, thymosin beta 4 stimulates tumor growth and metastasis by induction of cell migration and vascular endothelial growth factor-mediated angiogenesis. Using a construct on the skin-specific keratin-5 promoter, we have developed thymosin beta 4 over-expressing transgenic mice to further study its functional roles. Thymosin beta 4 in adult skin and in embryonic stages of the transgenic mouse was analyzed by both Western blot and immunohistochemistry. The over-expression of thymosin beta 4 was observed especially around hair follicles and in the teeth in the transgenic mice. We examined the phenotype of the thymosin beta 4 over-expressing mice. Hair growth was accelerated. In addition, the transgenic mice had abnormally-shaped white teeth and dull incisors. We found that the expression of laminin-5 was up-regulated in the skin of the transgenic mice. We conclude that thymosin beta 4 has an important physiological role in hair growth and in tooth development.</P>
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging
Park, Sung-Jun,Gavrilova, Oksana,Brown, Alexandra L.,Soto, Jamie E.,Bremner, Shannon,Kim, Jeonghan,Xu, Xihui,Yang, Shutong,Um, Jee-Hyun,Koch, Lauren G.,Britton, Steven L.,Lieber, Richard L.,Philp, And Elsevier 2017 Cell metabolism Vol.26 No.2