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Synthesis, Antinicrobial and Molluscicidal Activities of New Benzimidazole Derivatives
Nofal, Z.M.,Fanmy, H.H.,Mohamed, H.S. The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.1
A series of Schiff's benzimidazole bases, thiosemicarbazides were synthesized, azole ring systems as 1,3,4-triazole, 1,3,4-oxadiazole were prepared. 1-Methylbenzimidazole incorporated to substituted dithio-carbamate, thiophenol, diethylamine via acetamido group were synthesized. A series of pyrimidinobenzimidazoles, triazinobenz-imidazoles, and 2-(acetonylamino)-1-methyl-benzimidazole were prepared. The antimicrobial and molluscicidal activities of some newly prepared compounds were carried out.
Synthesis and Antimicrobial Activity of New Substituted Anili-nobenzimidazoles
Nofal, Z.M.,Fahmy, H.H.,Mohamed, H.S. The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.3
A series of benzimidazole derivatives carrying different heterocycles such as 1,2,3-thiadiazole, 1,3,4-thiadiazole, thiazolidine, 2,3-dihydro-thiazole, 1,3,4-oxadiazole, semicarbazone and substituted thiosemi-carbazones were synthesized. Also a series of 1-methylbenzimidazole carrying hydroxy ethyl-amide, substituted sulfonyl hydrazide and benzoyl hydrazide from aminobenzoyl group at position 2 of 1-methylbenzimidazole were synthesized. The antimicrobial evaluation of some of the new compounds was carried out.
Diaphragmatic Hernia with Gastric Volvulus and Complete Gastric Outlet Obstruction
Hayder Al-Masari,Heba Nofal,Rawan Majdalawi,Reham Ainawi,Abdulwahid Alwahedi,Tarek Mahdi 대한내시경복강경외과학회 2020 Journal of Minimally Invasive Surgery Vol.23 No.4
A combination of Cytoreductive surgery (CRS) along with hyperthermic intraperitoneal chemotherapy (HIPEC) considers a crucial approach in treating designated patients with alimentary and gynecological malignancies with the involvement of the peritoneal cavity. The foremost frequent surgical complications are leakage, digestive perforations, fistulas, intestinal obstruction, abscess, and peripancreatitis. This report presents a case of a patient with a late acquired herniation of guts through the diaphragm after CRS and HIPEC that were already done 6 months back. A 26 -year- old male previously treated with CRS and HIPEC for testicular mesothelioma with peritoneal involvement, was admitted to our unit with the diagnosis of gastric outlet obstruction. His CT scan illustrated a left diaphragmatic hernia involving the stomach and splenocolic flexure. Each denudation of the diaphragmatic serosa throughout CRS which typically occurs during the surgical operation in a combination of the HIPEC heat can explain such complication. The herniation is extremely uncommonly diagnosed after CRS and HIPEC. Surgical techniques for hernia repair can be done by direct suturing of the defect or closure with artificial or biological tissue, each technique is a potential surgical technique for repair with reliable long-run results.
Samar Reda Al‑Sayed,Haytham Elgazzar,Adel Nofal 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.11
To improve the poor wear resistance of titanium and its alloys, a blended powder consisting of 60 wt% tungsten carbide(WC) and 40 wt% NiCrSiBC was produced by Laser Metal Deposition (LMD) on the surface of Ti–6Al–4V (α + β) titaniumalloy. A 3 KW TRUDISK 3001 Yb:YAG disk laser (1030 nm wavelength) attached with a coaxial jet nozzle coupled with apowder feeding system was used in this study. Different powder feeding rates were used aiming to make the LMD processmore economic. In addition, the deposited layer performance at elevated temperature was also evaluated. The results showedcrack-free structures when using the optimized conditions. At a powder feeding rate of 20 ɡ min−1, the matrix structure consistsof a small continuous network of WC granular clusters in a solid solution of Cr in Ni and Ti alloy matrix. In contrast,at higher powder feeding rates of 40 and 60 ɡ min−1, such granular clusters transformed into mostly fragile needle-type androd-type W2Cthat grew epitaxially from the surface of the partially melted WC particles, respectively. The results showedan increase by more than four folds in the microhardness values of the clad layers in addition to a significant wear resistanceat 500 °C compared to that of Ti–6Al–4V substrates. A reduction by 66% in the friction coefficient at 60 ɡ min−1 wasrecorded as compared with the as-received samples. Such improvement in surface properties at elevated temperatures meetsthe industrial requirements for such engineering alloys.
Microscopic Study of Hydroxyapatite Dissolution As Affected by Fluoride Ions
Kwon, Ki-Young,Wang, Eddie,Nofal, Michel,Lee, Seung-Wuk American Chemical Society 2011 Langmuir Vol.27 No.9
<P>Fluoride ions play a critical role in preventing tooth decay. We investigated the microscopic effects of fluoride ions on hydroxyapatite (100) surface dissolution using in situ atomic force microscopy. In the presence of 10 mM NaF, individual surface step retraction velocities decreased by about a factor of 5 as compared to NaF-free conditions. Importantly, elongated hexagonal etch pits, which are characteristic of (100) surface dissolution, were no longer observed when NaF was present. The alteration of pit shape is more distinct at a higher NaF concentration (50 mM) where triangular etch pits evolved during dissolution. Furthermore, in a fluoride concentration typical for tap water (10 μM), we observed roughening of individual step lines, resulting in the formation of scalloped morphologies. Morphological changes to individual steps across a wide range of fluoride concentrations suggest that the cariostatic capabilities of fluoride ions originate from their strong interactions with molecular steps.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2011/langd5.2011.27.issue-9/la200325d/production/images/medium/la-2011-00325d_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la200325d'>ACS Electronic Supporting Info</A></P>
Potential therapeutic and pharmacological strategies for SARS-CoV2
Ghareeb Doaa A.,Saleh Samar R.,Nofal Mohammed S.,Kaddah Mohamed M. Y.,Hassan Salma. F.,Seif Inas K.,El-Zahaby Sally A.,Khedr Shaimaa M.,Kenawy Marwa Y.,Masoud Aliaa A.,Soudi Salma A.,Sobhy Ahmed A.,Se 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.3
Background At the end of 2019, the new Coronavirus disease 2019 (COVID-19) strain causing severe acute respiratory syndrome swept the world. From November 2019 till February 2021, this virus infected nearly 104 million, with more than two million deaths and about 25 million active cases. This has prompted scientists to discover effective drugs to combat this pandemic. Area covered Drug repurposing is the magic bullet for treating severe acute respiratory syndrome coronavirus 2 (SARSCoV2). Therefore, several drugs have been investigated in silico, in vitro, as well as through human trials such as anti- SARS-CoV2 agents, or to prevent the complications resulting from the virus. In this review, the mechanisms of action of different therapeutic strategies are summarized. According to the WHO, different classes of drugs can be used, including anti-malarial, antiviral, anti-inflammatory, and anti-coagulant drugs, as well as angiotensin-converting enzyme inhibitors, antibiotics, vitamins, zinc, neutralizing antibodies, and convalescent plasma therapy. Recently, there are some vaccines which are approved against SARS-CoV2. Expert opinion A complete understanding of the structure and function of all viral proteins that play a fundamental role in viral infection, which contribute to the therapeutic intervention and the development of vaccine in order to reduce the mortality rate.