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Proinvasive extracellular matrix remodeling for tumor progression
Neha Kaushik,Seungmo Kim,Yongjoon Suh,Su-Jae Lee 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.1
Cancer is a systemic disease in which neoplastic cells interact with multiple types of non-neoplastic stromal cells as well as non-cellular components. The extracellular matrix (ECM) is a non-cellular component that is aberrantly regulated in many types of tumor microenvironments. Since the ECM generally maintains the tissue structure and provides mechanical forces in the tumor microenvironment, it has been simply assumed to act as a physical barrier for cancer metastasis and have a passive role in cancer progression. However, a substantial body of evidence has suggested that ECM remodeling influences many aspects of cancer cell behaviors and its importance has attracted attention in cancer biology. Abnormal ECM affects cancer progression through several ways such as inducing hypoxia, immune cells interaction by promoting mesenchymal shift and cell transformation. Accordingly, in this review we summarize and discusses the role of the ECM in modulating epithelial cells and surrounding stomatal cell components and considers its prospects in cancer biology.
Kaushik, Nagendra Kumar,Kaushik, Neha,Min, Booki,Choi, Ki Hong,Hong, Young June,Miller, Vandana,Fridman, Alexander,Choi, Eun Ha IOP 2016 Journal of Physics. D, Applied Physics Vol.49 No.8
<P>The present study aims at studying the anticancer role of cold plasma-activated immune cells. The direct anti-cancer activity of plasma-activated immune cells against human solid cancers has not been described so far. Hence, we assessed the effect of plasma-treated RAW264.7 macrophages on cancer cell growth after co-culture. In particular, flow cytometer analysis revealed that plasma did not induce any cell death in RAW264.7 macrophages. Interestingly, immunofluorescence and western blot analysis confirmed that TNF-<I>α</I> released from plasma-activated macrophages acts as a tumour cell death inducer. In support of these findings, activated macrophages down-regulated the cell growth in solid cancer cell lines and induced cell death <I>in vitro</I>. Together our findings suggest plasma-induced reactive species recruit cytotoxic macrophages to release TNF-<I>α</I>, which blocks cancer cell growth and can have the potential to contribute to reducing tumour growth <I>in vivo</I> in the near future.</P>
Biological and medical applications of plasma-activated media, water and solutions
Kaushik, Nagendra Kumar,Ghimire, Bhagirath,Li, Ying,Adhikari, Manish,Veerana, Mayura,Kaushik, Neha,Jha, Nayansi,Adhikari, Bhawana,Lee, Su-Jae,Masur, Kai,von Woedtke, Thomas,Weltmann, Klaus-Dieter,Choi De Gruyter 2019 Biological chemistry Vol.400 No.1
<P><B>Abstract</B></P><P>Non-thermal atmospheric pressure plasma has been proposed as a new tool for various biological and medical applications. Plasma in close proximity to cell culture media or water creates reactive oxygen and nitrogen species containing solutions known as plasma-activated media (PAM) or plasma-activated water (PAW) - the latter even displays acidification. These plasma-treated solutions remain stable for several days with respect to the storage temperature. Recently, PAM and PAW have been widely studied for many biomedical applications. Here, we reviewed promising reports demonstrating plasma-liquid interaction chemistry and the application of PAM or PAW as an anti-cancer, anti-metastatic, antimicrobial, regenerative medicine for blood coagulation and even as a dental treatment agent. We also discuss the role of PAM on cancer initiation cells (spheroids or cancer stem cells), on the epithelial mesenchymal transition (EMT), and when used for metastasis inhibition considering its anticancer effects. The roles of PAW in controlling plant disease, seed decontamination, seed germination and plant growth are also considered in this review. Finally, we emphasize the future prospects of PAM, PAW or plasma-activated solutions in biomedical applications with a discussion of the mechanisms and the stability and safety issues in relation to humans.</P>