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RISS 인기검색어
- 검색키워드
- 저자 : Nackley, Andrea G. (검색결과 2 건)
- 무료
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Nackley, Lloyd L.,Jeong, Jig Han,Oki, Lorence R.,Kim, Soo-Hyung American Society for Horticultural Science 2016 Journal of the American Society for Horticultural Vol.141 No.4
<P>Garlic (<I>Allium sativum</I>) is a commercially and culturally important crop worldwide. Despite the importance of garlic, there have been few studies investigating how garlic growth and development will be affected by the atmospheric enrichment of carbon dioxide (CO2). A split-plot experiment with CO2 concentrations as main plot and nitrogen (N) fertilization as subplot was carried out to examine the effects of elevated CO2 at (mean ± sd) 745 ± 63 µmol·mol<SUP>−1</SUP> across three levels of N: high-N (16.0 mm), mid-N (4.0 mm), and low-N (1.0 mm). Three hypotheses were tested: 1) garlic plants will allocate proportionally more biomass to bulb when grown in elevated CO2 compared with the plants grown in ambient CO2; 2) plants will sustain improved photosynthesis without downregulation in elevated CO2, irrespective of N; and 3) elevated CO2 will improve plant water use efficiency (WUE) across N fertilization levels. We found that proportional biomass allocation to bulb was not significantly enhanced by CO2 enrichment in garlic. Overall biomass accumulation represented by leaf, stem, and bulb did not respond significantly to CO2 enrichment but responded strongly to N treatments (<I>P</I> < 0.001). Contrary to our hypothesis, photosynthetic downregulation was apparent for garlic plants grown in elevated CO2 with a decrease in Rubisco capacity (<I>P</I> < 0.01). Instantaneous leaf WUE improved in response to elevated CO2 (<I>P</I> < 0.001) and also with increasing N fertilization (<I>P</I> < 0.001). Finally, our results indicate that bulbing ratio is likely to remain unchanged with CO2 or N levels and may continue to serve as a useful nondesctructive metric to estimate harvest timing and bulb size.</P>
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Kim, Seungtae,Zhang, Xin,O'Buckley, Sandra C.,Cooter, Mary,Park, Jongbae J.,Nackley, Andrea G. Elsevier 2018 The journal of pain Vol.19 No.12
<P><B>Abstract</B></P> <P>Patients with chronic overlapping pain conditions have decreased levels of catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines. Consistent with clinical syndromes, we previously demonstrated that COMT inhibition in rodents produces persistent pain and heightened immune responses. Here, we sought to determine the efficacy of manual acupuncture in resolving persistent pain and neuroinflammation in the classic inbred C57BL/6 strain and the rapid-wound healing MRL/MpJ strain. Mice received subcutaneous osmotic minipumps to deliver the COMT inhibitor OR486 or vehicle for 13 days. On day 7 after pump implantation, acupuncture was performed at the Zusanli (ST36) point or a non-acupoint for 6 consecutive days. Behavioral responses to mechanical stimuli were measured throughout the experiment. Immunohistochemical analysis of spinal phosphorylated p38 mitogen-activated protein kinase, a marker of inflammation, and glial fibrillary acidic protein, a marker of astrogliosis, was performed on day 13. Results demonstrated that ST36, but not sham, acupuncture resolved mechanical hypersensitivity and reduced OR486-dependent increases in phosphorylated p38 and glial fibrillary acidic protein in both strains. The magnitude of the analgesic response was greater in MRL/MpJ mice. These findings indicate acupuncture as an effective treatment for persistent pain linked to abnormalities in catecholamine signaling and, furthermore, that analgesic efficacy may be influenced by genetic differences.</P> <P><B>Perspective</B></P> <P>Chronic overlapping pain conditions remain ineffectively managed by conventional pharmacotherapies. Here, we demonstrate that acupuncture alleviates persistent pain and neuroinflammation linked to heightened catecholaminergic tone. Mice with superior healing capacity exhibit greater analgesic efficacy. Findings indicate acupuncture as an effective treatment for chronic overlapping pain conditions and provide insight into treatment response variability.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Sustained inhibition of catechol-O-methyltransferase led to persistent pain and neuroinflammation in mice. </LI> <LI> ST36, but not sham, acupuncture alleviated pain. </LI> <LI> ST36 acupuncture reduced spinal phosphorylated p38 expression and astrocyte activation. </LI> <LI> The magnitude of the analgesic response was greater in rapid-healing MRL/MpJ mice. </LI> </UL> </P>
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