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RISS 인기검색어
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- 저자 : Mylvaganam, Geetha Hanna (검색결과 4 건)
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Velu, Vijayakumar,Mylvaganam, Geetha Hanna,Gangadhara, Sailaja,Hong, Jung Joo,Iyer, Smita S.,Gumber, Sanjeev,Ibegbu, Chris C.,Villinger, Francois,Amara, Rama Rao The American Association of Immunologists, Inc. 2016 JOURNAL OF IMMUNOLOGY Vol.197 No.5
<P>Chronic HIV infection is associated with accumulation of germinal center (GC) T follicular helper (Tfh) cells in the lymphoid tissue. The GC Tfh cells can be heterogeneous based on the expression of chemokine receptors associated with T helper lineages, such as CXCR3 (Th1), CCR4 (Th2), and CCR6 (Th17). However, the heterogeneous nature of GC Tfh cells in the lymphoid tissue and its association with viral persistence and Ab production during chronic SIV/HIV infection are not known. To address this, we characterized the expression of CXCR3, CCR4, and CCR6 on GC Tfh cells in lymph nodes following SIVmac251 infection in rhesus macaques. In SIV-naive rhesus macaques, only a small fraction of GC Tfh cells expressed CXCR3, CCR4, and CCR6. However, during chronic SIV infection, the majority of GC Tfh cells expressed CXCR3, whereas the proportion of CCR4(+) cells did not change, and CCR6(+) cells decreased. CXCR3(+), but not CXCR3(-), GC Tfh cells produced IFN-gamma (Th1 cytokine) and IL-21 (Tfh cytokine), whereas both subsets expressed CD40L following stimulation. Immunohistochemistry analysis demonstrated an accumulation of CD4(+) IFN-gamma(+) T cells within the hyperplastic follicles during chronic SIV infection. CXCR3(+) GC Tfh cells also expressed higher levels of ICOS, CCR5, and alpha 4 beta 7 and contained more copies of SIV DNA compared with CXCR3(-) GC Tfh cells. However, CXCR3(+) and CXCR3(-) GC Tfh cells delivered help to B cells in vitro for production of IgG. These data demonstrate that chronic SIV infection promotes expansion of Th1-biased GC Tfh cells, which are phenotypically and functionally distinct from conventional GC Tfh cells and contribute to hypergammaglobulinemia and viral reservoirs.</P>
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Naemonitou, Foteini,Mylvaganam, Senthurun,Salem, Fathi,Vidya, Raghavan Korean Society of Plastic and Reconstructive Surge 2020 Archives of Plastic Surgery Vol.47 No.6
Background Polyurethane implants have been used on and off in breast reconstruction since 1991 while prepectoral breast reconstruction has gained popularity in recent times. In this study, we present our outcomes from the use of acellular dermal matrix (ADM) complete wrap with polyurethane implants in prepectoral breast reconstruction. Methods This is a retrospective review of prospectively maintained database from 41 patients receiving complete ADM wrap with prepectoral polyurethane implants over a 3-year period. Selection criteria were adapted from a previous study (4135 Trust Clinical Audit Database) evaluating prepectoral reconstruction with Braxon matrices. Patient demographics, operative data, surgical complications, and outcomes were collected and analyzed. Results A total of 52 implant reconstructions were performed in 41 patients with a mean follow-up of 14.3 months (range, 6-36 months). The overall reported complication rates including early (less than 6 weeks) and late complications. Early complications included two patients (4.9%) with wound dehiscence. One of which had an implant loss that was salvageable. Another patient (2%) developed red-breast syndrome and two women (4.9%) developed with seroma treated conservatively. Late complications included one patient (2%) with grade II capsular contraction, 12 patients with grade I-II rippling and two patients (4.9%) with grade III rippling. Conclusions We present our experience of prepectoral polyurethane implant using complete ADM wrap. This is one of the few papers to report on the outcome of the prepectoral use of polyurethane in immediate implant-based breast reconstruction. Our early observational series show satisfactory outcome and long-term results are warranted by a large multicenter study.
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Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease
Lee, Jean-Pyo,Jeyakumar, Mylvaganam,Gonzalez, Rodolfo,Takahashi, Hiroto,Lee, Pei-Jen,Baek, Rena C,Clark, Dan,Rose, Heather,Fu, Gerald,Clarke, Jonathan,McKercher, Scott,Meerloo, Jennifer,Muller, Franz- Nature Publishing Group 2007 Nature medicine Vol.13 No.4
Intracranial transplantation of neural stem cells (NSCs) delayed disease onset, preserved motor function, reduced pathology and prolonged survival in a mouse model of Sandhoff disease, a lethal gangliosidosis. Although donor-derived neurons were electrophysiologically active within chimeric regions, the small degree of neuronal replacement alone could not account for the improvement. NSCs also increased brain β-hexosaminidase levels, reduced ganglioside storage and diminished activated microgliosis. Additionally, when oral glycosphingolipid biosynthesis inhibitors (β-hexosaminidase substrate inhibitors) were combined with NSC transplantation, substantial synergy resulted. Efficacy extended to human NSCs, both to those isolated directly from the central nervous system (CNS) and to those derived secondarily from embryonic stem cells. Appreciating that NSCs exhibit a broad repertoire of potentially therapeutic actions, of which neuronal replacement is but one, may help in formulating rational multimodal strategies for the treatment of neurodegenerative diseases.
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國際米作硏究所圃場에 있어서 寄生蜂에 의한 Scirpophaga incertulas의 卵寄生率에 대하여
H.S. KIM,E.A. HEINRICHS,P. MYLVAGANAM 한국응용곤충학회 1986 한국응용곤충학회지 Vol.25 No.1
필리핀에 있는 국제미작연구소(國際米作硏究所) 논 포장(圃場)에서 이앙(移秧)후 일(日) 된 묘(苗)에서 Scirpophaga incertulas의 난(卵)을 1984년(年) 7월 부터 10월 까지 채집(採集)하여 난기생봉(卵寄生蜂)의 기생율(寄生率) 및 생태(生態)를 조사한 결과(結果)는 다음과 같다. ScirpoPhaga incertulas 의 난(卵)에서 나온 벌목 천적(天敵)으로 Tetrasticus schoenobii, Telenomus rowani, Trichogramma japonicum 3종(三種)이 발견(發見)되었고 기생봉(寄生蜂)의 생물적(生物的)인 습성(習性)에 기초(基礎)를 둔 기생율(寄生率) 계산(計算)방법을 소개하였다. 난기생봉(卵寄生蜂) 3종(三種)의 공기생(共寄生) 조합(組合)은 T. rowani+T. japonicum 조합(組合)이 가장 많았고 T. rowani 는 단기생성(單寄生性) 천적(天敵)으로 우화성충(羽化成蟲) 수(數)가 가장 많았지만 3종(三種)의 기생봉중(寄生蜂中) T. schoenobii 는 유충기간(幼蟲期間) 중 Scirpophaga incertulas 의 난(卵)을 개(個) 소모(消耗)시키므로 가장 유용(有用)한 천적(天敵)이었으며 이 천적(天敵)의 1세대기간(世代期間)은 일(日) 이었다. We surveyed the IRRI farm to determine the extent of parasitization of yellow stemborer egg masses. The egg masses were randomly collected at weekly intervals from July to October 1984 from rice fields, 15-20 days after transplanting, and brought to the laboratory for collection of emerging parasites. Three species of hymenopterous parasitoids-Tetrasticus schoenobii, Telenomus rowani, and Trichogramma japonicum-were found from 700 egg masses. We introduced a method to calculate percent parasitism as based on parasite biology and behaviour. Among the three species, the combination of T. rowani and T. japonicum was the highest multiparasitization of yellow stem borer egg masses, and T. rowani, a solitary parasite had the highest number based on immature and adult stages counted. However, T. schoenobii may be the most efficient parasite because two to four host eggs are needed to complete the larval period, and it took days for one generation.
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