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        Synthesis, antimicrobial evaluation and molecular modelling of novel sulfonamides carrying a biologically active quinazoline nucleus

        Mostafa M. Ghorab,Zienab H. Ismail,Mohamad Abdalla,Awwad A. Radwan 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.6

        A novel series of quinazolines 5–10, triazoloquinazolines11–17 and triazinoquinazoline 19 bearing abiologically active sulfonamide moiety were synthesized,utilizing methyl 2-isothiocyanato benzoate 2. Some of thenewly synthesized compounds revealed promising bacterialgrowth inhibition, compared with the ampicillin, as thereference drug. A LigandScout approach-generated pharmacophoremodel for the Staph aureus bacteria growthinhibition was done. The degree of fitting of the test setcompounds (3, 4, 6, 8, 11, 17) to the generated hypotheticalmodel revealed a qualitative measure of the more orless microbial inhibition of Staphylococcus aureus. Compounds(7, 8, 10, 12, 15, 17 and 22), which revealed significantactivity, are able to effectively satisfy the proposedpharmacophore geometry, using the energy accessibleconformers (Econf\20 kcal/mol).

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        Towards Better Site Analysis in Architectural and Urban Design: Adapting Experiential Learning Theory in Post-COVID Architectural Teaching Methods

        Moohammed Wasim Yahia,Salem Buhashima Abdalla,Ahmad Sukkar,Ahmed Abdeen Saleem,Aref Mohamad Maksoud 한국디자인학회 2023 디자인학연구 Vol.36 No.4

        Background : Traditional design studios in architecture education have considerably been affected by COVID-19 since all teaching activities required a major shift from face-to-face to online. This study explores how students’ understanding of site analysis in architecture design courses was affected by COVID-19 in terms of visiting the site, understanding its context, perceiving its components, and collecting information on the site. Moreover, the study examines whether experiential learning theory could be applied as a vital teaching method for conducting site analysis for architecture and urban design students at the Department of Architectural Engineering, College of Engineering, University of “University of Sharjah”. Methods : To achieve the aim, in-depth interviews with fourteen students are conducted and analyzed using qualitative and quantitative methods. The aim of the interviews is based on investigating how COVID-19 affected the attitude of students when conducting the site analysis during the pandemic and comparing this with the same action after they returned to hybrid/on-campus courses. Results : The findings show that COVID-19 negatively affected students’ understanding of the site, particularly how they perceived the surrounding components and how they used these components in the design process. In this regard, students more often relied on their prior knowledge to analyze the site rather than visiting the site itself and exposing themselves to a new experience. For post-COVID education, considering experiential learning theory in the process of site analysis and applying its four stages (i.e., concrete experience, reflective observation, abstract conceptualization, and active experimentation) will increase the level of quality of teaching and learning outcomes in architecture and urban design curriculums. This in turn will enhance the pedagogical discussion within the Department of Architectural Engineering, University of “University of Sharjah”. Conclusions : In the hybrid teaching and learning style, the students have more ability to combine different tools after they visit the site, and the site analysis becomes easier. A second-time site visit as a second experience gives the impression that the students use the outcome of the first visit (as preknowledge) to further understand the situation through observations and conceptualization. The study highlights the role of different advanced online teaching and learning platforms in facilitating a high level of knowledge, especially when it comes to theoretical courses as well as pedagogical assistance on different levels.

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