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Piperine reduces hair oiliness by inhibiting adipogenesis of hair stem cells
Im Minyoung,Kim Nackhyoung,Park Ui-Hyun,Heo Hyeon Ho,Um Soo-Jong 한국응용생명화학회 2024 Applied Biological Chemistry (Appl Biol Chem) Vol.67 No.-
Piperine, an alkaloid compound in black pepper (Piper nigrum), has beneficial bioactivities. Specifically, piperine inhibits adipogenesis in 3T3-L1 cells by suppressing the transcriptional activity of PPARγ. Control of hair oiliness, which is related to adipogenic regulation, is important to prevent hair loss. Excessive sebum from the sebaceous gland (SG) can cause acne, folliculitis, or irritated skin by clogging pores. To investigate the in vivo function of piperine in SG, we used mice fed a high-fat diet (HFD). The HFD increased the size and Oil Red O (ORO) staining intensity of SG, which were significantly reduced by piperine. The HFD also upregulated the expression of sebocyte-associated genes, including PPARγ target genes, an effect reversed by piperine. In CD34/CD49f double positive hair follicle bulge stem cells isolated from mouse vibrissae, piperine inhibited cellular adipogenesis, likely via transcriptional repression of related genes. Furthermore, piperine reduced the thickness of subcutaneous fat. In human dermal papilla cells, piperine inhibited cellular adipogenesis, as shown by the reduction in ORO staining and the downregulation of PPARγ target genes. In conclusion, piperine can be used to reduce hair greasiness by suppressing adipogenesis in hair stem cells.
A Simple Method for Nanostructure Engineering of Mesoporous Zinc Silicate Particles
Choi, Hoon,Um, Kiju,Im, Minyoung,Lee, Kangtaek American Chemical Society 2015 Chemistry of materials Vol.27 No.7
<P>We report a novel method to engineer a nanostructure of zinc silicate particles. In this method, a mixture of tetraethoxysilane, zinc acetate, and cetyltrimethylammonium chloride (CTAC) was reacted in water at 80 °C for ∼3 h, followed by calcination. This method produced mesoporous zinc silicate particles with a core–shell structure in which the core contained a mixed oxide of ZnO and SiO<SUB>2</SUB>, whereas the shell was pure SiO<SUB>2</SUB>. We found a faster formation of mixed oxide than pure SiO<SUB>2</SUB>, which is believed to be responsible for the core–shell structure. On the basis of this understanding, we engineered the nanostructure of the synthesized particles: (1) zinc oxide in the core was dissolved by citrate buffer to produce hollow mesoporous silica particles, and (2) a layer-by-layer deposition technique was used to grow mesoporous shells on the existing particles, producing multishell mesoporous particles with various morphologies. Using a nitrogen sorption method, the average pore diameter of mesoporous zinc silicate particles was found to be 3.4 nm, which is similar to the diameter of spherical CTAC micelles. We also tested the adsorption capacity of hollow mesoporous silica particles using water-soluble anionic (8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt) and cationic (rhodamine B) dyes, and we found a high adsorption capacity for the cationic dye but negligible adsorption for the anionic dye. Finally, we compared release profiles of rhodamine B from hollow mesoporous silica particles with different morphologies.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2015/cmatex.2015.27.issue-7/cm503768j/production/images/medium/cm-2014-03768j_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cm503768j'>ACS Electronic Supporting Info</A></P>