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Cell Patterning on a Poly(2-hydroxyethyl methacrylate) Film Based on Interfacial Dynamics
Kento Kawabata,Masayasu Totani,Hisao Matsuno,Keiji Tanaka 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Thermal molecular motion in the outermost region of polymer films strongly impact on various material functions. Here we propose a novel concept for the two-dimensional (2D) regulation of chain dynamics at the water interface based on the introduction of silica nanoparticles (SiNP) into a polymer film, leading to the 2D-patterning of the fibroblast adhesion. A poly(2-hydroxyethyl methacrylate) (PHEMA) film was prepared on an SiNP line-patterned substrate. While X-ray photoelectron spectroscopic imaging confirmed that a whole outermost region of the film was fully covered with a single PHEMA component, atomic force microscopy-assisted force-distance curve measurements in water revealed that there were regions with different mechanical properties, that is, different interfacial dynamics, depending on the SiNP lines in the vicinity. On such a film, NIH3T3 cells showed heterogeneous adhesion and aggregates formation depending on the 2D-patterend interfacial dynamics.