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T Cell Receptor-MHC Class I Peptide Interactions : Affinity, Kinetics, and Specificity
Corr, Maripat,Slanetz, Alfred E.,Boyd, Lisa F.,Jelonek, Marie T.,Khilko, Sergei,Al-Ramadi, Basel K.,Kim, Young Sang,Maher, Stephen E.,Bothwell, Alfred L. M.,Margulies, David H. 충남대학교 생물공학연구소 1996 생물공학연구지 Vol.4 No.-
The critical discriminatory event in the activation of T lymphocytes bearing αβT cell receptors (TCRs) is their interaction with a molecular complex consisting of a peptide bound to a major histocompatibility complex (MHC)-encoded classⅠor class Ⅱ molecule on the surface of an antigen-presenting cell. The kinetics of binding were measured of a purified TCR to molecular complexes of a purified soluble analog of the murine MHC classⅠ molecule H-2L^d (sH-2L^d) and a synthetic octamer peptide p2CL in a direct, real-time assay based on surface plasmon resonance. The kinetic dissociation rate of the MHC-peptide complex from the TCR was rapid (2.6×10^-2) second^-1, corresponding to a half-time for dissociation of approximately 27 seconds), and the kinetic association rate was 2.1×10^ 5 M^-1 second^-1. The equilibrium constant for dissociation was approximately 10^-7M These values indicate that TCRs must interact with a multivalent array of MHC-peptide complexes to trigger T cell signaling.
Impact of molybdenum cross sections on FHR analysis
Kyle M. Ramey,Marat Margulis,Nathaniel Read,Eugene Shwageraus,Bojan Petrovic 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.3
A recent benchmarking effort, under the auspices of the Organization for Economic Cooperation andDevelopment (OECD) Nuclear Energy Agency (NEA), has been made to evaluate the current state ofmodeling and simulation tools available to model fluoride salt-cooled high temperature reactors (FHRs). The FHR benchmarking effort considered in this work consists of several cases evaluating the neutronicparameters of a 2D prismatic FHR fuel assembly model using the participants’ choice of simulation tools. Benchmark participants blindly submitted results for comparison with overall good agreement, exceptfor some which significantly differed on cases utilizing a molybdenum-bearing control rod. Participantsutilizing more recently updated explicit isotopic cross sections had consistent results, whereas thoseusing elemental molybdenum cross sections observed reactivity differences on the order of thousands ofpcm relative to their peers. Through a series of supporting tests, the authors attribute the differences asbeing nuclear data driven from using older legacy elemental molybdenum cross sections. Quantitativeanalysis is conducted on the control rod to identify spectral, reaction rate, and cross section phenomenaresponsible for the observed differences. Results confirm the observed differences are attributable to theuse of elemental cross sections which overestimate the reaction rates in strong resonance channels.