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M. Perwaiz Iqbal,Saeed Mahmood,Naseema Mehboobali,Mohammad Ishaq,Tasnim Fatima,Saddiqa Parveen,Philippe Frossard 생화학분자생물학회 2004 Experimental and molecular medicine Vol.36 No.2
The angiotensin converting enzyme (ACE) is a strong candidate gene for myocardial infarction (MI). Insertion-deletion dimorphism intron 16 of this gene has ben inconclusively found to be the ACE gene have been identified and among these, a dimorphism in exon 17, ACE G2350A, has a significant effect on plasma ACE concentra-tions. To ases the value of genotyping the ACE G2350A dimorphism in a geneticaly homogeneous population, we caried out a case-control study of dimorphism G2350A for a putative association with MI among Pakistani nationals. We inves-tigated a sample population of 370 Pakistanis, comprising 163 controls, and 207 patients with clinical diagnosis of acute MI (AMI). ACE G2350A merase chain reaction and restriction endonu-clease analysis. Frequencies of G alleles were 0.68 among controls and 0.72 among AMI patients. The ACE G2350A dimorphism showed no significant association with MI (χ2= 0.90, 2 df, P = 0.64), plasma levels of homocysteine (P = 0.52) or with serum levels of folate (P = 0.29). The results indi-cate that ACE G2350A polymorphism is not as-sociated with risk of myocardial infarction in the Pakistani population investigated here.