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RISS 인기검색어
- 검색키워드
- 저자 : M. A. Elkhamisy (검색결과 3 건)
- 무료
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NEW CCD OBSERVATIONS AND THE FIRST PHOTOMETRIC STUDY OF THE CONTACT BINARY AP UMI
N. S. AWADALLA,M. A. HANNA,M. N. Ismail,I. A. Hassan,M. A. Elkhamisy 한국천문학회 2016 Journal of The Korean Astronomical Society Vol.49 No.3
We obtain the first complete CCD light curves (LCs) of the contact binary AP UMi in the VRI bands and analyzed them by means of the PHOEBE code. A spotted model is applied to treat the asymmetry in the LCs. The LC morphology clearly shows the O'Connell effect and the solution shows an influence of star spots on both components. Such effect of star spots is common between the RS CVn and W UMa chromospherically active stars. Based on the obtained solution of the LCs we investigate the evolutionary state of the components and conclude that the system is a pre-intermediate contact binary ($f=0.29$) with mass ratio $q=0.38$, and it is an A-type W UMa system where the less massive secondary component is cooler than the more massive primary one.} We obtain the first complete CCD light curves (LCs) of the contact binary AP UMi in the VRI bands and analyzed them by means of the PHOEBE code. A spotted model is applied to treat the asymmetry in the LCs. The LC morphology clearly shows the O'Connell effect and the solution shows an influence of star spots on both components. Such effect of star spots is common between the RS CVn and W UMa chromospherically active stars. Based on the obtained solution of the LCs we investigate the evolutionary state of the components and conclude that the system is a pre-intermediate contact binary ($f=0.29$) with mass ratio $q=0.38$, and it is an A-type W UMa system where the less massive secondary component is cooler than the more massive primary one.
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Nadia El-Menshawy,Sherin M. Abd-Aziz,Enas M. Elkhamisy,Mohammed A. Ebrahim 대한혈액학회 2018 Blood Research Vol.53 No.2
Background Targeted therapy has revolutionized the management of Philadelphia chromo-some-positive (Ph+) acute lymphoblastic leukemia (ALL); however, relapse still occurs because of the presence of quiescent stem cells, termed leukemia propagating cells (LPCs). This study aimed to assess the phenotypic diversity of LPCs in adult patients with Ph+ B-Acute ALL (B-ALL) and to assess its prognostic impact. Methods Seventy adults with newly diagnosed Ph+ B-ALL were recruited at the Mansoura Oncology Center. Multiparameter flow cytometry studies of mononuclear blast cells for cluster of differentiation (CD)34, CD38, and CD58 were performed. Results Seventeen patients had blasts with the pattern of LPCs (CD34+CD38-CD58-), while 53 cases had other diverse phenotypic patterns. The rate of complete response was significantly lower in patients with the LPC phenotype (47% vs. 81%, P=0.006). The median time to achieve a complete response was prolonged in patients with the CD34+ CD38-CD58- phenotype (48 vs. 32 days, P=0.016). The three-year overall survival was significantly lower in patients with the CD34+CD38-CD58- phenotype (37% vs. 55% respectively, P=0.028). Multivariate analysis showed that the CD34+CD38- CD58- phenotype was an independent risk factor for overall survival. Conclusion The presence of CD34+CD38-CD58- LPCs at diagnosis allows rapid identification of higher risk patients. Risk stratification of these patients is needed to further guide therapy and develop effective LPCs-targeted therapy to improve treatment outcome.
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Nadia El-Menshawy,Sherin M. Abd-Aziz,Enas M. Elkhamisy,Mohammed A. Ebrahim 대한혈액학회 2018 Blood Research Vol.53 No.2
Background Targeted therapy has revolutionized the management of Philadelphia chromo-some-positive (Ph+) acute lymphoblastic leukemia (ALL); however, relapse still occurs because of the presence of quiescent stem cells, termed leukemia propagating cells (LPCs). This study aimed to assess the phenotypic diversity of LPCs in adult patients with Ph+ B-Acute ALL (B-ALL) and to assess its prognostic impact. Methods Seventy adults with newly diagnosed Ph+ B-ALL were recruited at the Mansoura Oncology Center. Multiparameter flow cytometry studies of mononuclear blast cells for cluster of differentiation (CD)34, CD38, and CD58 were performed. Results Seventeen patients had blasts with the pattern of LPCs (CD34+CD38-CD58-), while 53 cases had other diverse phenotypic patterns. The rate of complete response was significantly lower in patients with the LPC phenotype (47% vs. 81%, P=0.006). The median time to achieve a complete response was prolonged in patients with the CD34+ CD38-CD58- phenotype (48 vs. 32 days, P=0.016). The three-year overall survival was significantly lower in patients with the CD34+CD38-CD58- phenotype (37% vs. 55% respectively, P=0.028). Multivariate analysis showed that the CD34+CD38- CD58- phenotype was an independent risk factor for overall survival. Conclusion The presence of CD34+CD38-CD58- LPCs at diagnosis allows rapid identification of higher risk patients. Risk stratification of these patients is needed to further guide therapy and develop effective LPCs-targeted therapy to improve treatment outcome.
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