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- 저자 : Lubet, Ronald A. (검색결과 2 건)
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Social Confluence Theory, as Applied to Cases of Disability Status and Korean Identity
Alex Lubet,김향은 한국학중앙연구원 한국학중앙연구원 2015 THE REVIEW OF KOREAN STUDIES Vol.18 No.2
This paper presents an exposition of social confluence theory, a concept of identity formation first introduced by Alex Lubet. The theory posits that the fundamental unit of identity in globalized, high technology, information-oriented societies such as the United States and South Korea is no longer a relatively stable unit such as the nation-state, ethnic group, faith community, nuclear or extended family, or individual. Rather, it is the status of the individual or group within the sociocultural or psychosocial encounter of the moment, which we call the social confluence. We first demonstrate the application of the theory with examples from the intersection of disability and music. To further illustrate the theory’s potential, we apply it to Korean identity, demonstrating the great mutability of that identity across different contexts or social confluences, using examples from South Korea and the United States, including international Korean adoptees, North Korean refugees, and Korean and other Asian-Americans in pan-Asian arts organizations. We conclude by proposing research topics in disability studies and Korean studies for which social confluence theory seems particularly apt, in particular the categorizations of people with Autistic Spectrum Conditions, while proposing extended research applications for the theory, with particular attention toward South Korea.
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Ritter, Joseph K.,Chen, Fan,Sheen, Yhun Y.,Lubet, Ronald A.,Owens, Ida S. 이화여자대학교 생명과학연구소 1992 생명과학연구논문집 Vol.3 No.-
Two human liver UDP-glucuronosyltransferase cDNA clones, HLUG25[Jackson, M. R., et al.(1987) Biochem. J. 242 58-5881-588] and UDPGT_h-2 [Ritter, J.K.,et al.(1990). J Biol. Chem. 266, 7900-7906] have previously been shown to encode isozymes active in the glucuronidation of hyodeoxycholic acid (HDCA) and certain estrogen derivatives (estriols and 3,4-catechol estrogens), respetively. Here we report that the UDPGT_h-2-enconded isoform (udpgt_h-2) and the HLUG25-encoded isoform (udpgt_h-1) have parallel aglycon specificities. Following expression in COS-1 cells, each isoform metabolized three types of dihydroxy-or trihydroxy-substituted ring structures, in cluding the 3,4-catechol estrogen (4-hydroxyestrone), estriol and 17-epiestriol, and HDCA, but the udpgt_h-2 isozyme is 100-fold more efficient than udpgt_h-1 udpgt_h-1 and udpgt_h-2 are 86% identical oerall (76 differences out of 528 amino acids), including 55 differences in the first 300 amino acids of the amino terminus, a domain which confers isoform substrate specificity. The data indicate that a high level of conservation in the amino terminus is not required for the preservation of substrate seletivity. Analysis of glucuronidation activity encoded by UDPGT_h-1/udpgt_h-2 chimeric cDNA_s constructed at their ommon restriction sites, SacI (codon 297.,NcoI(codon 385), and HhaI (codon 469), showed that nine amino acids between residues 385 and 469 are important for catalytic efficiency, suggesting that this region represents a domain which is critial for catalysis but distinct from that responsible for aglycon selection. In parallel with the existence of liver and kidney microsomal HDCA glucuronosyl transferase activity, mRNA coding for udpgt_h-2 is expressed in liver and kidney, whereas that for udpgt_h-1 expressed only in the liver. These data indicate that udpgt_h-2 is a primary isoform responsible for the detoxification of the bile salt intermediate as well as the active estrogen intermediates.
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